TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*9.A.36.1.1









Erythrocyte Ca2+-dependent phospholipid scramblase 1, PLSCR1, of 318 aas and 1 or 2 C-terminal TMSs.  The C-terminal helix (CTH) inserts into the membrane via charge interactions but does not oligomerize in the membrane. The CTH is thus required for membrane insertion, Ca2+ coordination and the functional conformational changes that result in lipid scrambling (Francis et al. 2013).  The C-terminal region binds cholesterol (Posada et al. 2014). The role of this protein in phospholipid scrambling has been questioned (Sahu et al. 2007; Sivagnanam et al. 2017).

Eukaryota
Metazoa
Scramblase 1 of Homo sapiens (O15162)
*9.A.36.1.2









Scramblase homologue of327 aas and 1 C-terminal TMS.

Eukaryota
Fungi
Scramblase of Saccharomyces cerevisiae (P47140)
*9.A.36.1.3









Scramblase homologue of 305 aas and 1 C-terminal TMS.

Bacteria
Actinobacteria
Scramblase of Frankia alni (Q0RI11)
*9.A.36.1.4









Phospholipid scramblase 4, PLS4, PLSCR4 or GIG43 of 329 aas.  Accelerates ATP-independent bidirectional transbilayer flipping of phospholipids upon binding calcium ions. Results in loss of phospholipid asymmetry in the plasma membrane (Vinnakota and Gummadi 2016).

Eukaryota
Metazoa
PL scramblase of Homo sapiens (Human)
*9.A.36.1.5









Phospholipid scramblase-2, PLSCR2, of 297 aas and 3 putative TMSs (Wiedmer et al. 2000).

Eukaryota
Metazoa
PLSCR2 of Homo sapiens
*9.A.36.1.6









PLSCR3 of 295 aas and 1-3 TMSs (Wiedmer et al. 2000).

Eukaryota
Metazoa
PLSCR3 of Homo sapiens