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9.A.39.1.1
Iron-regulated surface determinant, hemoglobin/myoglobin (but not hemopexin) receptor (IsdB) precursor (645 aas) (believed to extract heme iron and transport it into the cell). The path way for uptake of heme from human methemoglobin by the iron-regulated surface determinants (Isd) is: B(9.A.39.1.1)→ A(9.A.39.1.3)→ C(9.A.39.1.4)→ E(3.A.1.14.18)→ DF(3.A.1.14.18)→ cytoplasm (Zhu et al., 2008).

Accession Number:Q6GHV7
Protein Name:Iron-regulated surface determinant protein B aka IsdB
Length:652
Molecular Weight:72999.00
Species:Staphylococcus aureus (strain MRSA252) [282458]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Secreted1 / Peptidoglycan-anchor2
Substrate iron-heme complex

Cross database links:

HEGENOM: HBG215818 HBG215818
RefSeq: YP_040515.1   
Entrez Gene ID: 2859674   
Pfam: PF00746    PF05031    PF04650   
BioCyc: SAUR282458:SAR1102-MONOMER   
KEGG: sar:SAR1102    sar:SAR1102   

Gene Ontology

GO:0009986 C:cell surface
GO:0005618 C:cell wall
GO:0005576 C:extracellular region
GO:0016020 C:membrane
GO:0046872 F:metal ion binding
GO:0009405 P:pathogenesis

References (4)

[1] “Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance.”  Holden M.T.G.et.al.   15213324
[2] “Neutrophil microbicides induce a pathogen survival response in community-associated methicillin-resistant Staphylococcus aureus.”  Palazzolo-Ballance A.M.et.al.   18097052
[3] “Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance.”  Holden M.T.G.et.al.   15213324
[4] “Neutrophil microbicides induce a pathogen survival response in community-associated methicillin-resistant Staphylococcus aureus.”  Palazzolo-Ballance A.M.et.al.   18097052

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNKQQKEFKS FYSIRKSSLG VASVAISTLL LLMSNGEAKA AEETGVTNTE AQPKTEAVAS 
61:	PTTTTTEKAP EAKPVAKPVA NAVSVSNKEV VAPTTETKEA KEVKAVKEVK APKEAKEEKP 
121:	AAKADNNTYP ILNQELREAI KNPAIKDKDH SAPNSRPIDF EMKKKDGTQQ FYHYASSVKP 
181:	ARVIFTDSKP EIELGLQSGQ FWRKFEVYEG DKKLPIKLVS YDTVKDYAYI RFSVSNGTKA 
241:	VKIVSSTHFN NKEEKYDYTL MEFAQPIYNS ADKFKTEEDY KAEKLLAPYK KAKTLERQVY 
301:	ELNKIQDKLP EKLKAEYKKK LEETKKALDE QVKSAITEFQ NVQPTNEKMT DLQDTKYVVY 
361:	ESVENNESMM DAFVKHPIKT GMLNGKKYMV METTNDDYWK DFMVEGQRVR TISKDAKNNT 
421:	RTIIFPYVEG KTLYDAIVKV HVKTIDYDGQ YHVRIVDKEA FTKANADKTN KKEQQDNSAK 
481:	KETTPAMPSK PTTPPVEKES QKQDSQKDDN KQSPSVEKEN DASSESGKDK MPVTKPAKAE 
541:	VESSSTTPTK VVSTTQNVAK PTTASSETTK DVVQTSAGSS EAKDSAPLQK ANIKNTNDGH 
601:	TQSQNNKNTQ ENKAKSLPQT GEESNKDMTL PLMALIALSS IVAFVLPRKR KN