TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*9.A.40.1.1









Hemolysin C, HlyC
Bacteria
Spirochaetes
HlyC of Brachyspira (Treponema, Serpulina) hyodysenteriae (Q54318)
*9.A.40.1.2









Co2+-resistance protein, CorC.  The E. coli orthologue (P6AE78) is 97% identical to the S. enterica protein.

Bacteria
Proteobacteria
CorC of Salmonella typhimurium (P0A2L3)
*9.A.40.1.3









Uncharacterized protein of 384 aas and 3 or 4 N-terminal TMSs.  The region of sequence similarity with established CorC proteins is in a hydrophilic region following the TMSs, putting into question the assignment of this protein to family 9.A.40.

Bacteria
Candidatus Saccharibacteria
UP of Candidatus Saccharibacteria bacterium
*9.A.40.1.4









Uncharacterized protein of 384 aas and 4 TMSs.  The region of sequence similarity with established CorC proteins is in a hydrophilic region following the TMSs, putting into question the assignment of this protein to family 9.A.40. The N-terminal domain of 100 aas and 2 TMSs does not show sequence similarity with anything outside of the Candidatus Saccharibacteria bacteria.

Bacteria
Candidatus Saccharibacteria
UP of Candidatus Saccharibacteria bacterium
*9.A.40.2.1









Hypothetical Protein, YrkA
Bacteria
Firmicutes
YrkA of Bacillus subtilis (P54428)
*9.A.40.2.2









Putative hemolysin of 452 aas, TylC-like (Sałamaszyńska-Guz and Klimuszko 2008).

Bacteria
Proteobacteria
TylC-like protein of Campylobacter jejuni
*9.A.40.2.3









Uncharacterized protein of 444 aas and 4 TMSs, YhdP.  Mutations in yhdP increase the activity of sigmaW, suggesting that this transporter may be an MDR exporter (Turner and Helmann 2000).

Bacteria
Firmicutes
YhdP of Bacillus subtilis
*9.A.40.2.4









CorC homologue, YfjD, of 428 aas and 4 TMSs.  In a two gene operon with YpjD, a putative cytochrome c assembly protein (P64432; TC# 9.B.14.3.6).

Bacteria
Proteobacteria
YfjD of E. coli
*9.A.40.3.1









Kidney metal (Mg2+) transporter, Cyclin (CNN) M2 isoform CRA_b. Defects cause hypomagnesemia. Has an extracellular N-terminus and an intracellular C-terminus (de Baaij et al., 2012). CNNM2a forms heterodimers with the smaller isoform CNNM2b.  The human splice variant 1 of CNNM2 (ACDP2; Q9H8M5)is a Mg2+ transporter (Brandao et al. 2012).  The Bateman module is involved in AMP binding and Mg2+ sensing, and their binding causes a conformational change in the CBS module, transmitted to the transmembrane domain (Corral-Rodríguez et al. 2014).

Eukaryota
Metazoa
Cyclin M2 of Mus musculus (Q3TWN3)
*9.A.40.3.2









Metal transporter CNNM3 (Ancient conserved domain-containing protein 3) (mACDP3) (Cyclin-M3) of 713 aas and probably 5 TMSs with one N-terminal, and four together in the first half of the protein (Chen et al. 2018). See the family description for the domain order of the CNNM proteins.

Eukaryota
Metazoa
CNNM3 of Mus musculus
*9.A.40.3.3









Metal transporter CNNM3 (Ancient conserved domain-containing protein 3) (Cyclin-M3).  As of 2018, the function of this protein as a Mg2+ transporter is under debate (Schäffers et al. 2018).

Eukaryota
Metazoa
CNNM3 of Homo sapiens
*9.A.40.3.4









Metal transporter CNNM4 (Ancient conserved domain-containing protein 4) (Cyclin-M4).  As of 2018, the function of this protein as a Mg2+ transporter was under debate (Schäffers et al. 2018).

Eukaryota
Metazoa
CNNM4 of Homo sapiens
*9.A.40.3.5









Mg2+ exporter of 951 aas and 5 TMSs in a 1 + 4 TMS arrangement, CNNM1 (Chen et al. 2018).

Eukaryota
Metazoa
CNNM1 of Homo sapiens
*9.A.40.3.6









Putative Mg2+ exporter of 875 aas and 5 TMSs, CNNM2 or ACDP2 (Chen et al. 2018).

Eukaryota
Metazoa
CNNM2 of Homo sapiens
*9.A.40.3.7









Uncharacterized protein of 734 aas and 5 N-terminal TMSs.

Eukaryota
Kinetoplastida
UP of Trypanosoma cruzi