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9.A.52 The Microcin J25 (Microsin J25) Family

Microcin J25 (MccJ25) is a cyclic peptide of 21 unmodified amino acis residues produced by a fecal strain of Escherichia coli. It is mainly directed to Enterobacteriaceae, including several pathogenic E. coli, Salmonella and Shigella strains. Rintoul et al., 2001 showed that MccJ25 acts on the cytoplasmic membrane of Salmonella newport cells producing alterations of the membrane permeability, and subsequent ion gradient dissipation. This initiates the growth inhibition process. This suggest that the disruption of the cytoplasmic memrbane gradient is closely related to the bactericidal activity of MccJ25.The structure of Microcin J25 is known (1S7P_A), but its mechanism of action is not.

The reaction probably catalyzed by MccJ25 is:

cations (in) cations (out)

References associated with 9.A.52 family:

Rintoul, M.R., B.F. de Arcuri, R.A. Salomón, R.N. Farías, and R.D. Morero. (2001). The antibacterial action of microcin J25: evidence for disruption of cytoplasmic membrane energization in Salmonella newport. FEMS Microbiol. Lett. 204: 265-270. 11731133
Socias, S.B., K. Severinov, and R.A. Salomon. (2009). The Ile13 residue of microcin J25 is essential for recognition by the receptor FhuA, but not by the inner membrane transporter SbmA. FEMS Microbiol. Lett. 301: 124-129. 19843311