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9.A.54.1.2
Probable lysosomal cobalamin transporter of 646 aas and 7 TMSs in a 5 + 2 + hydrophilic domain arrangement.

Accession Number:Q2HDJ0
Protein Name:Probable lysosomal cobalamin transporter
Length:646
Molecular Weight:70835.00
Species:Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) [306901]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Lysosome membrane1 / Multi-pass membrane protein2
Substrate lysosomal cobalamin

Cross database links:

Entrez Gene ID: 4386940   
Pfam: PF04791   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005765 C:lysosomal membrane
GO:0031419 F:cobalamin binding
GO:0006810 P:transport

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAPAGLLQTS LIWVAYGVAV ALVLLVSVIT TLTWQTPHER SIAVSIVSII SLTALLATVF 
61:	LLPVDIALVS STASAHLGAK KDWATPGRVD GILLTLKIVY YTLYTLDALL CLIVIPFTYF 
121:	WFEEYDEVEE EEGTSSAAAR IWRALKYTLG FVFLVVILFL IGFFVPAAGN NPGKHMDLDY 
181:	FKRLLAANNG EKALTFGVGL LITLGTLLYI LYTSAGLALL PVSFIKSAPS ISAPQLSATT 
241:	ASALEHNREL QRQLEMRNSG RPEGMSQKDR REMDALLREE RTLVRRERLA AEARGDNRSK 
301:	IYRAWTKVEA VFRPLKLLGG IFLLLLAILI WVSMLITGID KAANSICKQH CGYILGHLNV 
361:	FQPINWIFVQ SAKAFPVDYI LMALLVLLFF SSSITGLATI GIRFLWVRIF QLKKGRTAPQ 
421:	ALLIATVLLG PHDPRHQLRG RHARGAAVRH LRHADLLRQP AAATRASSPT AASTATWCAP 
481:	APRPSASPAA IGRLHADRHV HLPQPRPPSN WPRLRRPSTS GPSSSSSPSS SSSSSPASSR 
541:	TPRLNLSELD EEAEVDERGG PAGPAPAAAL ARPGAISPAA PRRTPPRRAR RVMARRLGTR 
601:	MGVGRARGVK LNGGAATEND KKEKKNGTWV WAWVWEWEWQ TDWLAE