TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*9.A.54.1.1









Probable lysosomal cobalamin exporter, NESI or C61F disease protein; defective in cobalamin F type disease (540aas; 9 TMSs in a 5 + 4 arrangement) (Ruivo et al., 2009; Rutsch et al., 2009; Gailus et al., 2010; Wilcken, 2012) (also called LMBR1 domain-containing protein; liver regeneration p53-related protein, Lipocalin-interacting membrane receptor, limb region 1 protein, etc.) Homologues are present in all eukaryotes and probably some bacteria (e.g., EcsB protein of Bacillus cereus (gi#47570159; 10 TMSs; distantly related to 3.A.1.128.2). RodA of E. coli (9.B.3.1.2) may also be distantly related.

Eukaryota
Metazoa
NESI of Homo sapiens (Q9NUN5)
*9.A.54.1.2









Probable lysosomal cobalamin transporter of 646 aas and 7 TMSs in a 5 + 2 + hydrophilic domain arrangement.

Eukaryota
Fungi
CHGG_01714 of Chaetomium globosum
*9.A.54.1.3









Probable lysosomal cobalamine exporter of 590 aas and 9 putative TMSs.

Eukaryota
Fungi
Cobalamine exporter of Ajellomyces capsulatus (Darling's disease fungus) (Histoplasma capsulatum)
*9.A.54.1.4









Conserved plant hypothetical protein (9 TMSs)

Eukaryota
Viridiplantae
Hypothetical protein of Ricinus communis (B9SQ26)
*9.A.54.1.5









Uncharacterized protein of 476 aas and 9 TMSs in a 5 + 4 arrangement.

Eukaryota
Kinetoplastida
UP of Trypanosoma cruzi
*9.A.54.2.1









Hypothetical alveolata protein conserved in Plasmodium species, of 585 aas and 9 TMSs in a 5 + 4 arrangement).

Eukaryota
Apicomplexa
Hypothetical protein of Plasmodium knowlesi (B3L7M4)

 
*9.A.54.3.1









LMBR1-like conserved protein of 612 aas and 9 TMSs in a 5 + 4 TMS arrangement.

Eukaryota
Intramacronucleata
LMBR1-like protein of Tetrahymena thermophila (Q22WA5)
*9.A.54.3.2









Uncharacterized protein of 609 aas and 9 TMSs in a 5 + 4 TMS arrangement.

Eukaryota
Fungi
UP of Torulaspora delbrueckii (Candida colliculosa)
*9.A.54.3.3









Uncharacterized protein of 741 aas and 9 or 10 TMSs in a 5 + 4 or 5 TMS.

Eukaryota
Bangiophyceae
UP of Cyanidioschyzon merolae
*9.A.54.3.4









LMBR1 protein homologue of 537 aas

Eukaryota
Viridiplantae
LMBR1 homologue of Ostreococcus tauri
*9.A.54.4.1









Uncharacterized protein of 635 aas and 9 or 10 TMSs in a 5 (or 6) + hydrophilic domain + 4 TMSs + another hydrophilic domain.  The protein shows very little sequence similarity with other members of this family.

Archaea
Euryarchaeota
UP of Methanosphaera stadtmanae