The SRP-independent protein to endoplasmic reticulum insertion SND complex, Snd1(877 aas and 0 TMSs), Snd2 (181 aas and 4 TMSs; TMEM208; see 9.B.26) and Snd3 (188 aas and 2 or 3 TMSs). These proteins probably function in an SRP (signal recognition particle)- and GET (guided entry of tail-anchored proteins)-independent pathway for targeting a broad range of substrate proteins to the endoplasmic reticulum. The SND pathway functions in parallel to GET in targeting proteins with downstream hydrophobic motifs (Aviram et al. 2016).
SND pathway of Saccharomyces cerevisiae (Baker's yeast)