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9.A.70 The Mitochondrial Aspartate Amino Transferase (AAT) Family

The mitochondrial AAT (GOT2) catalyzes the irreversible transamination of the L-tryptophan metabolite, L-kynurenine, to form kynurenic acid (KA), playing a key role in amino acid metabolism. It is important for metabolite exchange between mitochondria and cytosol and facilitates cellular uptake of long-chain free fatty acids (Zhou et al. 1998).  It is regulated by AS160 which generally regulates energy utilization including Glut4 translocation to the plasma membrane (Mikłosz et al. 2016).

References associated with 9.A.70 family:

Mikłosz, A., B. Łukaszuk, M. Żendzian-Piotrowska, K. Kurek, and A. Chabowski. (2016). The Effects of AS160 Modulation on Fatty Acid Transporters Expression and Lipid Profile in L6 Myotubes. Cell Physiol Biochem 38: 267-282. 26784579
Zhou, S.L., R.E. Gordon, M. Bradbury, D. Stump, C.L. Kiang, and P.D. Berk. (1998). Ethanol up-regulates fatty acid uptake and plasma membrane expression and export of mitochondrial aspartate aminotransferase in HepG2 cells. Hepatology 27: 1064-1074. 9537447