9.B.101 The Cytotoxin-associated Gene Product (CagA) Family
Sequence analyses of the virulence determinant CagA revealed three main groups strikingly similar to the three groups of VacA sequences (see TC family 1.C.9). Thus, positive selection has shaped the phylogenetic structure of VacA and CagA, and each of these virulence determinants has evolved separately from the core genome. CagA may also be related to members of the Bacillus thuringiensis Vegetative Insecticidal Protein-3 (Vip3) Family (e.g., 1.C.105.2.2).
Hydrogen oxidation provides an alternative high-energy substrate for some pathogens. Wang et al. 2016 demonstrated roles of H2 oxidation in energizing transport of CagA, a carcinogenic toxin.