9.B.109 The Putative Archaeal 2 TMS Holin (A2-Hol) Family
The archaeon, Candidatus Nitrosoarchaeum limnia, encodes adjacent genes designated Toxin Secretion/Lysis Holin. The 'toxin' gene encodes a soluble protein of 325 aas stated as belonging to the 'Glycosyltransferase GBT-type Superfamily'. This protein brings up other glycosyltransferases in NCBI BLAST searches. The adjacent gene encodes as small protein of 132 aas and 2 TMSs that could be a holin, based on its size and topology. This protein has the UniProt accession number of S2E3C4 and has been assigned TC# 9.B.109.1.1. Paralogues are found in this same organism and other closely related species.