TCDB is operated by the Saier Lab Bioinformatics Group

9.B.113 The Collagen Secretory Protein, Mia3 (Mia3) Family

Melanoma inhibitory activity member 3 (MIA3/TANGO1) is an evolutionarily conserved endoplasmic reticulum resident transmembrane protein. Recent in vitro studies have shown that it is required for the loading of collagen VII into COPII-coated transport vesicles. Wilson et al. (2011) showed that mice lacking Mia3 are defective for the secretion of numerous collagens, including collagens I, II, III, IV, VII, and IX. Collagen deposition by these cell types is abnormal, and the extracellular matrix composition is compromised. These changes are associated with intracellular accumulation of collagen and the induction of a strong unfolded protein response, primarily within the developing skeleton. Chondrocyte maturation and bone mineralization are severely compromised in Mia3-null embryos, leading to dwarfism and neonatal lethality. Thus, Mia3 may be required for the efficient secretion of all collagens in higher organisms (Wilson et al., 2011).

References associated with 9.B.113 family:

Bard, F., L. Casano, A. Mallabiabarrena, E. Wallace, K. Saito, H. Kitayama, G. Guizzunti, Y. Hu, F. Wendler, R. Dasgupta, N. Perrimon, and V. Malhotra. (2006). Functional genomics reveals genes involved in protein secretion and Golgi organization. Nature 439: 604-607. 16452979
Elliott, L., I. Moore, and C. Kirchhelle. (2020). Spatio-temporal control of post-Golgi exocytic trafficking in plants. J Cell Sci 133:. 32102937
Ishikawa, Y., S. Ito, K. Nagata, L.Y. Sakai, and H.P. B├Ąchinger. (2016). Intracellular mechanisms of molecular recognition and sorting for transport of large extracellular matrix molecules. Proc. Natl. Acad. Sci. USA 113: E6036-E6044. 27679847
Lerner, D.W., D. McCoy, A.J. Isabella, A.P. Mahowald, G.F. Gerlach, T.A. Chaudhry, and S. Horne-Badovinac. (2013). A Rab10-dependent mechanism for polarized basement membrane secretion during organ morphogenesis. Dev Cell 24: 159-168. 23369713
Saito, K. and M. Maeda. (2019). Not just a cargo receptor for large cargoes; an emerging role of TANGO1 as an organizer of ER exit sites. J Biochem 166: 115-119. 31098622
Santos, A.J., C. Nogueira, M. Ortega-Bellido, and V. Malhotra. (2016). TANGO1 and Mia2/cTAGE5 (TALI) cooperate to export bulky pre-chylomicrons/VLDLs from the endoplasmic reticulum. J. Cell Biol. 213: 343-354. 27138255
Wilson, D.G., K. Phamluong, L. Li, M. Sun, T.C. Cao, P.S. Liu, Z. Modrusan, W.N. Sandoval, L. Rangell, R.A. Carano, A.S. Peterson, and M.J. Solloway. (2011). Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse. J. Cell Biol. 193: 935-951. 21606205