9.B.115 The Putative Integral Membrane Steroid 5α-reductase (SαR) Family
The proteins of the DUF1295 Superfamily, present in bacteria and eukaryotes, appear to be of unknown function. However, several entries in NCBI are annotated as various enzymes. The most common annotation names several of these homologues as putative steroid 5α-reductases. There are thousands of homologues in the NCBI database as of October, 2013. All are integral membrane proteins, most with 6-9 TMSs.