9.B.123 The Lysosomal 7-TMS (TM7SF1) Family
The TM7SF1 is a primarily lysosomal protein of 399aas in humans with 7 TMSs. It bears a dileucine-lysosomal targetting sequence and form putative N-glycosylation sites (Gao et al., 2012). Gao et al. (2012) suggest that it is a G-protein coupled receptor functioning in signal transduction across the lysosomal membrane. If so, it is very sequence divergent from the GPCR receptors in TC family 9.A.14.