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9.B.16.1.1
Ductin (vacuolar ATPase subunit c proteolipid)

Accession Number:P23380
Protein Name:Vacuolar ATP synthase 16 kDa proteolipid subunit aka EC 3.6.3.14 aka Ductin aka VHA16K
Length:159
Molecular Weight:16267.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate small molecules

Cross database links:

eggNOG: inNOG09278
DIP: DIP-19390N
RefSeq: NP_476801.1    NP_724474.1    NP_724475.1    NP_724476.1   
Entrez Gene ID: 44307   
Pfam: PF00137   
BioCyc: DMEL-XXX-02:DMEL-XXX-02-003053-MONOMER    DMEL-XXX-02:DMEL-XXX-02-003054-MONOMER    DMEL-XXX-02:DMEL-XXX-02-003055-MONOMER    DMEL-XXX-02:DMEL-XXX-02-003056-MONOMER   
KEGG: dme:Dmel_CG3161   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0045263 C:proton-transporting ATP synthase complex, c...
GO:0033179 C:proton-transporting V-type ATPase, V0 domain
GO:0005774 C:vacuolar membrane
GO:0015078 F:hydrogen ion transmembrane transporter acti...
GO:0005515 F:protein binding
GO:0015986 P:ATP synthesis coupled proton transport
GO:0033227 P:dsRNA transport

References (4)

[1] “Sequence of a cDNA from Drosophila coding for the 16 kD proteolipid component of the vacuolar H(+)-ATPase.”  Meagher L.et.al.   2147478
[2] “Evidence that the 16 kDa proteolipid (subunit c) of the vacuolar H(+)- ATPase and ductin from gap junctions are the same polypeptide in Drosophila and Manduca: molecular cloning of the Vha16k gene from Drosophila.”  Finbow M.E.et.al.   7983150
[3] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[4] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSSEVSSDNP IYGPFFGVMG AASAIIFSAL GAAYGTAKSG TGIAAMSVMR PELIMKSIIP 
61:	VVMAGIIAIY GLVVAVLIAG ALEEPSKYSL YRGFIHLGAG LAVGFSGLAA GFAIGIVGDA 
121:	GVRGTAQQPR LFVGMILILI FAEVLGLYGL IVAIYLYTK