TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*9.B.20.1.1









Putative Mg2+ transporter, MgtC (Retamal et al. 2009). The MgtC virulence protein binds to the F-type ATP synthase and maintains ATP homeostasis required for pathogenesis during phagosome acidification (Lee and Lee 2015).

 

Bacteria
Proteobacteria
MgtC of Salmonella typhimurium
*9.B.20.1.2









Putative Mg2+ transporter, virulence factor, MgtC.  The C-terminal domain is a divergent ACT domain (Yang et al. 2012).  The claim that MgtC is a Mg2+ transporter has been refuted (Yang et al. 2012).

Bacteria
Actinobacteria
MgtC of Mycobacterium tuberculosis
*9.B.20.1.3









Fungal MgtC homologue (Gastebois et al. 2011).

Eukaryota
Fungi
MgtC homologue of Aspergillus fumigatus
*9.B.20.1.4









Magnesium uptake system of 215 aas and 4 or 5 TMSs, YhiD (YhhE; MgtC).  This protein seems to be a low affinity magnesium uptake protein that could function either as a channel or a carrier (Ishijima et al. 2015).

Bacteria
Proteobacteria
YhiD of E. coli
*9.B.20.1.5









MgtC of 230 aas and 4 N-terminal TMSs.  Under Mg2+ limitation, P. aeruginosa MgtC prevents biofilm formation. It is expressed at high levels in macrophage and is important for multiplication inside macrophages. MgtC is required for optimal growth in Mg2+ deprived media (Bernut et al. 2015).

Bacteria
Proteobacteria
MgtC of Pseudomonas aeruginosa
*9.B.20.2.1









CysR-controlled, sulfur deprivation-induced protein
Bacteria
Cyanobacteria
SrpB of Synechococcus PCC7942
*9.B.20.2.2









Eukaryotic MgtC homologue, SrpB (163aas; 5 TMSs) 

Eukaryota
Viridiplantae
SrpB of Ricinus communis (B9TCJ7)
*9.B.20.3.1









COG3174 family member (548 aas; 14 TMSs in a 5+5+4 arrangement)

Archaea
Euryarchaeota
COG3174 family member of Halobacterium salinarium (Q9HPQ3)
*9.B.20.3.2









MgtC/SapB transporter (415aas; 14 TMSs in a 5+5+4 arrangement).

Archaea
Euryarchaeota
MgtC/SapB homologue of Halorubrum lacusprofundi (B9LV18)
*9.B.20.3.3









Azo1681 (422aas; 14TMSs in a 5+5+4 arrangement)

Bacteria
Proteobacteria
Azo1681 of Azoarcus sp. BH72 (A1K643)
*9.B.20.3.4









Uncharacterized protein of 277 aas and 9 TMSs.

Bacteria
Proteobacteria
UP of Bdellovibrio bacteriovorus