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9.B.20.1.1
Putative Mg2+ transporter, MgtC (Retamal et al. 2009). The MgtC virulence protein binds to the F-type ATP synthase and maintains ATP homeostasis required for pathogenesis during phagosome acidification (Lee and Lee 2015).  

Accession Number:P22037
Protein Name:ATMC aka MgtC aka STM3764
Length:231
Molecular Weight:25065.00
Species:Salmonella typhimurium [90371]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Mg2+

Cross database links:

HEGENOM: HBG708751
RefSeq: NP_462663.1   
Entrez Gene ID: 1255288   
Pfam: PF02308   
BioCyc: STYP99287:STM3764-MONOMER   
KEGG: stm:STM3764   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0009405 P:pathogenesis

References (6)

[1] “The mgtB Mg2+ transport locus of Salmonella typhimurium encodes a P-type ATPase.”  Snavely M.D.et.al.   1824701
[2] “The SPI-3 pathogenicity island of salmonella enterica.”  Blanc-Potard A.-B.et.al.   9922266
[3] “Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.”  McClelland M.et.al.   11677609
[4] “The Salmonella selC locus contains a pathogenicity island mediating intramacrophage survival.”  Blanc-Potard A.-B.et.al.   9311997
[5] “Magnesium and the role of MgtC in growth of Salmonella typhimurium.”  Moncrief M.B.C.et.al.   9673265
[6] “The MgtC virulence factor of Salmonella enterica serovar Typhimurium activates Na(+),K(+)-ATPase.”  Guenzel D.et.al.   16855249

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEERMLMFPY ILNLLAAMLL GALIGAERQW RQRMAGLRTN ALVATGAAVF ILSSMTTSPD 
61:	SPGRIAAQIV SGIGFLGAGV IMREGMNVRG LNTAATLWCS AGIGVLCGLG QFKNALAATI 
121:	IILCANILLR EAAQRINQLP ISAEGEKRYI LKVTCNKEDE SAVRQWLLNI VKEAAICLQG 
181:	LGSVPAQEQG YKEIRAELVG HADYRKTREL IISRIGDNDN ITAIHWSIDS Q