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9.B.20.1.4
Magnesium uptake system of 215 aas and 4 or 5 TMSs, YhiD (YhhE; MgtC).  This protein seems to be a low affinity magnesium uptake protein that could function either as a channel or a carrier (Ishijima et al. 2015). It plays a role in acid resistance at high cell densities together with the 6 TMS HdeD protein that may be an organic acid exporter (TC# 9.B.36.1.1) (Mates et al. 2007). The mgtC gene, which is present in S. enterica but not in E. coli, is responsible for the differences in RpoS accumulation between these two bacterial species. Thus, bacteria possess a mechanism to control RpoS accumulation responding to cytoplasmic Mg2+ levels, the difference of which causes distinct RpoS accumulation in closely related bacterial species (Park et al. 2018).

Accession Number:P0AFV2
Protein Name:Putative magnesium transporter YhiD
Length:215
Molecular Weight:23213.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Mg2+

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FASTA formatted sequence
1:	MTAEFIIRLI LAAIACGAIG MERQMRGKGA GLRTHVLIGM GSALFMIVSK YGFADVLSLD 
61:	HVGLDPSRIA AQVVTGVGFI GAGNILVRNQ NIVGLTTAAD IWVTAAIGMV IGSGMYELGI 
121:	YGSVMTLLVL EVFHQLTFRL MNKNYHLQLT LVNGNTVSML DWFKQQKIKT DLVSLQENED 
181:	HEVVAIDIQL HATTSIEDLL RLLKGMAGVK GVSIS