TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*9.B.20.1.1









Putative Mg2+ transporter, MgtC (Retamal et al. 2009). The MgtC virulence protein binds to the F-type ATP synthase and maintains ATP homeostasis required for pathogenesis during phagosome acidification (Lee and Lee 2015). The mgtC gene, which is present in S. enterica but not in E. coli, is responsible for the differences in RpoS accumulation between these two bacterial species. Thus, bacteria possess a mechanism to control RpoS accumulation responding to cytoplasmic Mg2+ levels, the difference of which causes distinct RpoS accumulation patterns in closely related bacterial species (Park et al. 2018).

 

Bacteria
Proteobacteria
MgtC of Salmonella typhimurium
*9.B.20.1.2









Putative Mg2+ transporter, virulence factor, MgtC.  The C-terminal domain is a divergent ACT domain (Yang et al. 2012).  The claim that MgtC is a Mg2+ transporter has been refuted (Yang et al. 2012).

Bacteria
Actinobacteria
MgtC of Mycobacterium tuberculosis
*9.B.20.1.3









Fungal MgtC homologue (Gastebois et al. 2011).

Eukaryota
Fungi
MgtC homologue of Aspergillus fumigatus
*9.B.20.1.4









Magnesium uptake system of 215 aas and 4 or 5 TMSs, YhiD (YhhE; MgtC).  This protein seems to be a low affinity magnesium uptake protein that could function either as a channel or a carrier (Ishijima et al. 2015). It plays a role in acid resistance at high cell densities together with the 6 TMS HdeD protein that may be an organic acid exporter (TC# 9.B.36.1.1) (Mates et al. 2007). The mgtC gene, which is present in S. enterica but not in E. coli, is responsible for the differences in RpoS accumulation between these two bacterial species. Thus, bacteria possess a mechanism to control RpoS accumulation responding to cytoplasmic Mg2+ levels, the difference of which causes distinct RpoS accumulation in closely related bacterial species (Park et al. 2018).

Bacteria
Proteobacteria
YhiD of E. coli
*9.B.20.1.5









MgtC of 230 aas and 4 N-terminal TMSs.  Under Mg2+ limitation, P. aeruginosa MgtC prevents biofilm formation. It is expressed at high levels in macrophage and is important for multiplication inside macrophages. MgtC is required for optimal growth in Mg2+ deprived media (Bernut et al. 2015).

Bacteria
Proteobacteria
MgtC of Pseudomonas aeruginosa
*9.B.20.2.1









CysR-controlled, sulfur deprivation-induced protein
Bacteria
Cyanobacteria
SrpB of Synechococcus PCC7942
*9.B.20.2.2









Eukaryotic MgtC homologue, SrpB (163aas; 5 TMSs) 

Eukaryota
Viridiplantae
SrpB of Ricinus communis (B9TCJ7)
*9.B.20.3.1









COG3174 family member (548 aas; 14 TMSs in a 5+5+4 arrangement)

Archaea
Euryarchaeota
COG3174 family member of Halobacterium salinarium (Q9HPQ3)
*9.B.20.3.2









MgtC/SapB transporter (415aas; 14 TMSs in a 5+5+4 arrangement).

Archaea
Euryarchaeota
MgtC/SapB homologue of Halorubrum lacusprofundi (B9LV18)
*9.B.20.3.3









Azo1681 (422aas; 14TMSs in a 5+5+4 arrangement)

Bacteria
Proteobacteria
Azo1681 of Azoarcus sp. BH72 (A1K643)
*9.B.20.3.4









Uncharacterized protein of 277 aas and 9 TMSs.

Bacteria
Proteobacteria
UP of Bdellovibrio bacteriovorus
*9.B.20.4.1









DUF4956 domain containing protein of 230 aas and 5 N-terminal TMSs.  Within the Pfam MgtC family.

Bacteria
Bacteroidetes
MgtC family protein of Alloprevotella rava
*9.B.20.4.2









DUF4956 domain containing protein of 215 aas and 4 or 5 TMSs.

Bacteria
Actinobacteria
DUF4956 domain protein of Streptomyces kanamyceticus
*9.B.20.4.3









Uncharacterized protein of 193 aas and 5 N-terminal TMSs.

Bacteria
Bacteroidetes
UP of Chryseobacterium hungaricum
*9.B.20.4.4









DUF4956 domain-containing protein of 229 aas and 3 - 4 TMSs.

Bacteria
Firmicutes
DUC4956 protein of Streptococcus mutans
*9.B.20.4.5









DUF4956 domain-containing protein of 243 aas and 3 - 4 TMSs.

Bacteria
Proteobacteria
DUF4956 domain protein of Endozoicomonas elysicola
*9.B.20.4.6









Uncharacterized protein of 224 aas and 3 or 4 TMSs.

Bacteria
Candidatus Magasanikbacteria
UP of Candidatus Magasanikbacteria bacterium GW2011