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9.B.21.2.1
The CyaY protein of 106 aas is an iron transport protein for iron-sulfur (Fe-S) cluster biosynthetic systems (Uchida et al. 2017). It also transports iron to ferrochelatase that catalyzes insertion of Fe2+ into protoporphyrin IX. Uchida et al. 2017 found that CyaY has the ability to bind heme as well as iron.

Accession Number:P27838
Protein Name:CyaY protein
Length:106
Molecular Weight:12231.00
Species:Escherichia coli [83333]
Location1 / Topology2 / Orientation3: Mitochondrion1
Substrate Unknown

Cross database links:

Genevestigator: P27838
EchoBASE: EB1606
EcoGene: EG11653
eggNOG: COG1965
HEGENOM: HBG687517
DIP: DIP-9356N
RefSeq: AP_003993.1    NP_418251.1   
Entrez Gene ID: 947754   
Pfam: PF01491   
BioCyc: EcoCyc:EG11653-MONOMER    ECOL168927:B3807-MONOMER   
KEGG: ecj:JW3779    eco:b3807   

Gene Ontology

GO:0005829 C:cytosol
GO:0008199 F:ferric iron binding
GO:0008198 F:ferrous iron binding
GO:0016226 P:iron-sulfur cluster assembly
GO:0006461 P:protein complex assembly

References (8)

[1] “The complete nucleotide sequence of the adenylate cyclase gene of Escherichia coli.”  Aiba H.et.al.   6393056
[2] “Comparative analysis of the cya locus in enterobacteria and related Gram-negative facultative anaerobes.”  Trotot P.et.al.   8874804
[3] “Analysis of the Escherichia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes.”  Daniels D.L.et.al.   1379743
[4] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[5] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[6] “Phylogeny of adenylyl cyclases.”  Danchin A.et.al.   8418825
[7] “Knock-out of the cyaY gene in Escherichia coli does not affect cellular iron content and sensitivity to oxidants.”  Li D.S.et.al.   10452520
[8] “Crystal structure of Escherichia coli CyaY protein reveals a previously unidentified fold for the evolutionarily conserved frataxin family.”  Cho S.-J.et.al.   10908679
Structure:
1EW4   1SOY   2EFF   2P1X     

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

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FASTA formatted sequence
1:	MNDSEFHRLA DQLWLTIEER LDDWDGDSDI DCEINGGVLT ITFENGSKII INRQEPLHQV 
61:	WLATKQGGYH FDLKGDEWIC DRSGETFWDL LEQAATQQAG ETVSFR