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9.B.22.1.2
Inner membrane autotransporter assembly factor TamB (YtfN). Part of the translocation and assembly module (TAM) autotransporter assembly complex, which functions together with TamA and Omp85, both in the outer membrane (TC#1.B.33) to translocate autotransporters across the outer membrane (Selkrig et al. 2012). TamB has a signal-anchor linkage to the inner membrane, beta-helical structure, conserved domain architecture and a C-terminal region that mimics outer membrane protein beta-strands (Heinz et al. 2015).  It may function in folding of the passe3nger domain while BamA-TamAB catalyze membrane β-domain insertion (M. Babu et al., manuscript in preparation).

Accession Number:P39321
Protein Name:Translocation and assembly module TamB
Length:1259
Molecular Weight:136780.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Single-pass membrane protein2
Substrate proteins

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MSLWKKISLG VVIVILLLLG SVAFLVGTTS GLHLVFKAAD RWVPGLDIGK VTGGWRDLTL 
61:	SDVRYEQPGV AVKAGNLHLA VGLECLWNSS VCINDLALKD IQVNIDSKKM PPSEQVEEEE 
121:	DSGPLDLSTP YPITLTRVAL DNVNIKIDDT TVSVMDFTSG LNWQEKTLTL KPTSLKGLLI 
181:	ALPKVAEVAQ EEVVEPKIEN PQPDEKPLGE TLKDLFSRPV LPEMTDVHLP LNLNIEEFKG 
241:	EQLRVTGDTD ITVSTMLLKV SSIDGNTKLD ALDIDSSQGI VNASGTAQLS DNWPVDITLN 
301:	STLNVEPLKG EKVKLKMGGA LREQLEIGVN LSGPVDMDLR AQTRLAEAGL PLNVEVNSKQ 
361:	LYWPFTGEKQ YQADDLKLKL TGKMTDYTLS MRTAVKGQEI PPATITLDAK GNEQQVNLDK 
421:	LTVAALEGKT ELKALLDWQQ AISWRGELTL NGINTAKEFP DWPSKLNGLI KTRGSLYGGT 
481:	WQMDVPELKL TGNVKQNKVN VDGTLKGNSY MQWMIPGLHL ELGPNSAEVK GELGVKDLNL 
541:	DATINAPGLD NALPGLGGTA KGLVKVRGTV EAPQLLADIT ARGLRWQELS VAQVRVEGDI 
601:	KSTDQIAGKL DVRVEQISQP DVNINLVTLN AKGSEKQHEL QLRIQGEPVS GQLNLAGSFD 
661:	RKEERWKGTL SNTRFQTPVG PWSLTRDIAL DYRNKEQKIS IGPHCWLNPN AELCVPQTID 
721:	AGAEGRAVVN LNRFDLAMLK PFMPETTQAS GIFTGKADVA WDTTKEGLPQ GSITLSGRNV 
781:	QVTQTVNDAA LPVAFQTLNL TAELRNNRAE LGWTIRLTNN GQFDGQVQVT DPQGRRNLGG 
841:	NVNIRNFNLA MINPIFTRGE KAAGMVSANL RLGGDVQSPQ LFGQLQVTGV DIDGNFMPFD 
901:	MQPSQLAVNF NGMRSTLAGT VRTQQGEIYL NGDADWSQIE NWRARVTAKG SKVRITVPPM 
961:	VRMDVSPDVV FEATPNLFTL DGRVDVPWAR IVVHDLPESA VGVSSDVVML NDNLQPEEPK 
1021:	TASIPINSNL IVHVGNNVRI DAFGLKARLT GDLNVVQDKQ GLGLNGQINI PEGRFHAYGQ 
1081:	DLIVRKGELL FSGPPDQPYL NIEAIRNPDA TEDDVIAGVR VTGLADEPKA EIFSDPAMSQ 
1141:	QAALSYLLRG QGLESDQSDS AAMTSMLIGL GVAQSGQIVG KIGETFGVSN LALDTQGVGD 
1201:	SSQVVVSGYV LPGLQVKYGV GIFDSIATLT LRYRLMPKLY LEAVSGVDQA LDLLYQFEF