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9.B.26 The Regulator of ER Stress and Autophagy TMEM208 (TMEM208) Family

TMEM208 family proteins are small protein of about 175 aas and 4 TMSs that appear to play roles in ER stress and autophagy regulation (Zhao et al. 2013).  These proteins are constituents of the SRP-independent targeting (SND) Family (TC# 9.A.64) (Aviram et al. 2016). Understanding protein targeting to the endoplasmic reticulum (ER) was expanded by the discovery of multiple pathways that function in parallel to the signal recognition particle (SRP). Guided entry of tail-anchored proteins and SRP independent (SND) systems are two such targeting pathways described in yeast. hSnd2 is the first constituent of the human SND pathway able to support substrate-specific protein targeting to the ER. Similar to its yeast counterpart, hSnd2 is assumed to function as a membrane-bound receptor preferentially targeting precursors carrying C-terminal transmembrane domains. Thus, hSnd2 is part of a complex network of targeting and translocation that is dynamically regulated (Haßdenteufel et al. 2017).

References associated with 9.B.26 family:

Aviram, N., T. Ast, E.A. Costa, E.C. Arakel, S.G. Chuartzman, C.H. Jan, S. HaƟdenteufel, J. Dudek, M. Jung, S. Schorr, R. Zimmermann, B. Schwappach, J.S. Weissman, and M. Schuldiner. (2016). The SND proteins constitute an alternative targeting route to the endoplasmic reticulum. Nature 540: 134-138. 27905431
HaƟdenteufel, S., M. Sicking, S. Schorr, N. Aviram, C. Fecher-Trost, M. Schuldiner, M. Jung, R. Zimmermann, and S. Lang. (2017). hSnd2 protein represents an alternative targeting factor to the endoplasmic reticulum in human cells. FEBS Lett. 591: 3211-3224. 28862756
Zhao, Y., J. Hu, G. Miao, L. Qu, Z. Wang, G. Li, P. Lv, D. Ma, and Y. Chen. (2013). Transmembrane protein 208: a novel ER-localized protein that regulates autophagy and ER stress. PLoS One 8: e64228. 23691174