TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*9.B.27.1.1









The YdjX protein. While not individually essential, the eight E. coli DedA family proteins are collectively essential (Boughner and Doerrler 2012).

Bacteria
Proteobacteria
YdjX of E. coli
*9.B.27.1.2









The YdjZ protein.  While not individually essential, the eight E. coli DedA family proteins are collectively essential (Boughner and Doerrler 2012).

Bacteria
Proteobacteria
YdjZ of E. coli
*9.B.27.1.3









DedA homologue; possible phospholipase D/transphosphatidylase domain protein 

Bacteria
Actinobacteria
DedA of Rhodococcus ruber
*9.B.27.1.4









Hypothetical protein of 195 aas and 5 TMSs

Bacteria
Planctomycetes
HP of Rhodopirellula baltica
*9.B.27.1.5









DedA-domain protein of 179 aas and 5 TMSs.

Bacteria
Chloroflexi
DedA protein of Anaerolinea thermophila
*9.B.27.1.6









TVP38/TMEM64 family protein, YdjX, of 215 aas and 5 TMSs in a 2 + 3 TMS arrangement.

Bacteria
Firmicutes
TVP38 protein of Terribacillus saccharophilus
*9.B.27.1.7









Oxalate exporter, Fp0AR (Watanabe et al. 2010).

Eukaryota
Fungi
Fp0AR of Fomitopsis palustris (D7UNZ8)
*9.B.27.1.8









Transmembrane protein 41B, TMEM41B, of 291 aas and 5 TMSs.  It is required for normal motor neuron development as well as autophagosome formation (Morita et al. 2018; Shoemaker et al. 2019).

Eukaryota
Metazoa
TMEM41B of Homo sapiens (Human)
*9.B.27.1.9









Transmembrane protein 41A, MEM41A, of 264 aas and 5 TMSs in a 1 + 2 + 2 TMS arrangement. TMEM41A is associated with metastasis via the modulation of E‑cadherin (Lin et al. 2018)

Eukaryota
Metazoa
TMEM41A of Homo sapiens
*9.B.27.1.10









Stasimon or TMEM41b of 320 aas and 5 or 6 TMSs in a probable 1 + 2 + 2 + 1 TMS arrangement.  The protein localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development (Van Alstyne et al. 2018).

Eukaryota
Metazoa
Stasimon of Drosophila melanogaster (Fruit fly)
*9.B.27.1.11









TVP38/TMEM64 family protein of 205 aas and 5 TMSs in a 3 + 3 TMS arrangement.

Bacteria
Cyanobacteria
VTT-domain-containing protein of Planktothrix paucivesiculata
*9.B.27.2.1









The YghB protein of 219aas and 5-6 TMSs. When both YghB and YqjA (TC# 9.b.27.2.2) are mutated, cells become alkaline tolerant and resistant to dyes and antibiotics, and a cell division defect is observed (Thompkins et al., 2008).  The YqjA protein is 60% identical to YghB, and these two act synergistically to maintain a normal pmf (Kumar and Doerrler 2015). Both of these proteins can replace a deleted DedA protein, DbcA, in Burkholderia thailandensis (Panta et al. 2019).

Bacteria
Proteobacteria
YghB of E. coli (P0AA60)
*9.B.27.2.2









The YqjA protein is 60% identical to YghB, and these two act synergistically to maintain a normal pmf (Kumar and Doerrler 2015). Perhaps secondarily, when both YghB and YqjA are mutated, the cells exhibit a cell division defect (Thompkins et al., 2008). It has been proposed that YqjA possesses proton-dependent transport activity that is stimulated by osmolarity and that it plays a significant role in the survival of E. coli at alkaline pH, perhaps as an osmosensory cation-dependent proton transporter (a cation:proton antiporter?) (Kumar and Doerrler 2015).

Bacteria
Proteobacteria
YqjA of E. coli 220aas; (220 aas; 6TMSs; 3+3) P0AA63
*9.B.27.2.3









DedA (SNARE-associated protein) (Putative selenite transport protein, Ledgham et al., 2005). Topology known (Daley et al., 2005)

Bacteria
Proteobacteria
DedA of E.coli (P0ABP6)
*9.B.27.2.4









The DedA family member involved in selenite uptake (Ledgham et al., 2005)

Bacteria
Proteobacteria
DedA of Ralstonia (Cupriavidus) metallidurans (ABF09780)
*9.B.27.2.5









The SNARE-associated Golgi protein (206 aas; 5 TMSs)

Archaea
Parvarchaeota
SNARE-associated Golgi protein of Candidatus Parvarchaeum acidiphilum ARMAN-5 (D6GX19)
*9.B.27.2.7









Uncharacterized protein of 192 aas

Bacteria
Proteobacteria
UP of E. coli
*9.B.27.2.8









DedA homologue of 211 aas and 5 TMSs.

Bacteria
Spirochaetes
DedA of Treponema pedis
*9.B.27.2.9









DedA homologue of 200 aas and 5 TMSs.

Bacteria
Candidatus Wolfebacteria
DedA of Candidatus Wolfebacteria bacterium
*9.B.27.2.10









DedA homologue of 216 aas and 5 TMSs.

Bacteria
Candidatus Wolfebacteria
DedA of Candidatus Wolfebacteria bacterium
*9.B.27.2.11









DedA protein, DbcA, of 253 aas and 6 TMSs in a 3 + 3 TMS arrangement. Direct measurement of the membrane potential revealed that B. thailandensis ΔdbcA is partially depolarized. This loss of the pmf may lead to alterations in LPS structure as wellas severe colistin sensitivity (Panta et al. 2019).

Bacteria
Proteobacteria
DbcA of Burkholderia thailandensis
*9.B.27.2.12









Three domain protein of 770 aas and 12 TMSs with a 6 TMS DedA domain at the N-terminus (PF01569), a central 6 TMS PF09335 domain characteristic of TC family # 9.B.105, and a C-terminal glycosyl transferase domain with 0 TMSs. The protein was annotated because of this last domain (dolichyl-phosphate beta-D-mannosyltransferase) which shows sequence similarity with proteins in TC families 4.D.1 and 4.D.2. Of the tree domains, the DedA domain comes up with the highest scores in a TC Blast search.

Bacteria
Actinobacteria
3 domain protein of Nocardioides sp. CF8
*9.B.27.2.13









Mannosyltransferase  with 3 C-terminal TMSs in a 2 + 1 TMS arrangement. It is involved in N-Glycan biosynthesis and displays an unexpected minimal cellulose-synthase-like fold (Gandini et al. 2020).

Archaea
Crenarchaeota
MT of Pyrobaculum calidifontis
*9.B.27.3.1









DedA; SNARE-associated superfamilly member of 142 aas and 4 TMSs.

Bacteria
Proteobacteria
DedA homologue of E. coli
*9.B.27.3.2









DedA homologue of 157 aas and 4 TMSs in a 2 + 2 arrangement.

Bacteria
Proteobacteria
DedA homologue of Haemophilus influenzae
*9.B.27.3.3









Putative DedA protein of 145 aas and 4 tMSs

Bacteria
Proteobacteria
DedA homologue of Pseudomonas putidas
*9.B.27.4.1









Hypothetical SNARE-associated protein of 6 putative TMSs in a 3 + 3 arrangement.

Bacteria
Planctomycetes
HP of Rhodopirellula baltica
*9.B.27.4.2









VTT domain-containing protein of 216 aas and 5 TMSs in a 3 + 2 TMS arrangement.

Bacteria
Planctomycetes
VTT domain protein of Roseimaritima sp.
*9.B.27.5.1









TMEM64 of 380 aas and 6 TMSs.  Functions as a regulator of the SERCA2 Ca2+ ATPase (TC# 3.A.3.2.7) by direct interaction, thereby regulating Ca2+ oscillations (Kim et al. 2013).

Eukaryota
Metazoa
TMEM64 of Homo sapiens
*9.B.27.5.2









Tvp38p SNARE-associated Golgi protein (COG398)

Eukaryota
Fungi
Tvp38 of Saccharomyces cerevisiae
*9.B.27.5.3









Uncharaterized protein (DedA homologue) of 312 aas and 6 TMSs.

Eukaryota
Viridiplantae
DedA homologue of Glycine max