TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*9.B.27.1.1









The YdjX protein. While not individually essential, the eight E. coli DedA family proteins are collectively essential (Boughner and Doerrler 2012).

Bacteria
Proteobacteria
YdjX of E. coli
*9.B.27.1.2









The YdjZ protein.  While not individually essential, the eight E. coli DedA family proteins are collectively essential (Boughner and Doerrler 2012).

Bacteria
Proteobacteria
YdjZ of E. coli
*9.B.27.1.3









DedA homologue

Bacteria
Actinobacteria
DedA of Rhodococcus ruber
*9.B.27.1.4









Hypothetical protein of 195 aas and 5 TMSs

Bacteria
Planctomycetes
HP of Rhodopirellula baltica
*9.B.27.1.5









DedA-domain protein of 179 aas and 5 TMSs.

Bacteria
Chloroflexi
DedA protein of Anaerolinea thermophila
*9.B.27.1.6









TVP38/TMEM64 family protein, YdjX, of 215 aas and 5 TMSs in a 2 + 3 TMS arrangement.

Bacteria
Firmicutes
TVP38 protein of Terribacillus saccharophilus
*9.B.27.2.1









The YghB protein. When both YghB and YqjA are mutated, a cell division defect (219aas; 4-6TMSs) is observed (Thompkins et al., 2008).  The YqjA protein is 60% identical to YghB, and these two act synergistically to maintain a normal pmf (Kumar and Doerrler 2015).

Bacteria
Proteobacteria
YghB of E. coli (P0AA60)
*9.B.27.2.2









The YqjA protein is 60% identical to YghB, and these two act synergistically to maintain a normal pmf (Kumar and Doerrler 2015). Perhaps secondarily, when both YghB and YqjA are mutated, the cells exhibit a cell division defect (Thompkins et al., 2008). It has been proposed that YqjA possesses proton-dependent transport activity that is stimulated by osmolarity and that it plays a significant role in the survival of E. coli at alkaline pH, perhaps as an osmosensory cation-dependent proton transporter (a cation:proton antiporter?) (Kumar and Doerrler 2015).

Bacteria
Proteobacteria
YqjA of E. coli 220aas; (220 aas; 6TMSs; 3+3) P0AA63
*9.B.27.2.3









DedA (SNARE-associated protein) (Putative selenite transport protein, Ledgham et al., 2005). Topology known (Daley et al., 2005)

Bacteria
Proteobacteria
DedA of E.coli (P0ABP6)
*9.B.27.2.4









The DedA family member involved in selenite uptake (Ledgham et al., 2005)

Bacteria
Proteobacteria
DedA of Ralstonia (Cupriavidus) metallidurans (ABF09780)
*9.B.27.2.5









The SNARE-associated Golgi protein (206 aas; 5 TMSs)

Archaea
Parvarchaeota
SNARE-associated Golgi protein of Candidatus Parvarchaeum acidiphilum ARMAN-5 (D6GX19)
*9.B.27.2.6









Oxalate exporter, Fp0AR (Watanabe et al. 2010).

Eukaryota
Fungi
Fp0AR of Fomitopsis palustris (D7UNZ8)
*9.B.27.2.7









Uncharacterized protein of 192 aas

Bacteria
Proteobacteria
UP of E. coli
*9.B.27.2.8









DedA homologue of 211 aas and 5 TMSs.

Bacteria
Spirochaetes
DedA of Treponema pedis
*9.B.27.2.9









DedA homologue of 200 aas and 5 TMSs.

Bacteria
Candidatus Wolfebacteria
DedA of Candidatus Wolfebacteria bacterium
*9.B.27.2.10









DedA homologue of 216 aas and 5 TMSs.

Bacteria
Candidatus Wolfebacteria
DedA of Candidatus Wolfebacteria bacterium
*9.B.27.3.1









DedA; SNARE-associated superfamilly member of 142 aas and 4 TMSs.

Bacteria
Proteobacteria
DedA homologue of E. coli
*9.B.27.3.2









DedA homologue of 157 aas and 4 TMSs in a 2 + 2 arrangement.

Bacteria
Proteobacteria
DedA homologue of Haemophilus influenzae
*9.B.27.3.3









Putative DedA protein of 145 aas and 4 tMSs

Bacteria
Proteobacteria
DedA homologue of Pseudomonas putidas
*9.B.27.4.1









Hypothetical SNARE-associated protein of 6 putative TMSs in a 3 + 3 arrangement.

Bacteria
Planctomycetes
HP of Rhodopirellula baltica
*9.B.27.5.1









TMEM64 of 380 aas and 6 TMSs.  Functions as a regulator of the SERCA2 Ca2+ ATPase (TC# 3.A.3.2.7) by direct interaction, thereby regulating Ca2+ oscillations (Kim et al. 2013).

Eukaryota
Metazoa
TMEM64 of Homo sapiens
*9.B.27.5.2









Tvp38p SNARE-associated Golgi protein (COG398)

Eukaryota
Fungi
Tvp38 of Saccharomyces cerevisiae
*9.B.27.5.3









Uncharaterized protein (DedA homologue) of 312 aas and 6 TMSs.

Eukaryota
Viridiplantae
DedA homologue of Glycine max