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9.B.27.2.1
The YghB protein. When both YghB and YqjA are mutated, a cell division defect (219aas; 4-6TMSs) is observed (Thompkins et al., 2008).  The YqjA protein is 60% identical to YghB, and these two act synergistically to maintain a normal pmf (Kumar and Doerrler 2015).

Accession Number:P0AA60
Protein Name:YghB
Length:219
Molecular Weight:24134.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

Genevestigator: P0AA60
EchoBASE: EB1771
EcoGene: EG11824
eggNOG: COG0586
HEGENOM: HBG657460
RefSeq: AP_003560.1    NP_417482.1   
Entrez Gene ID: 947490   
Pfam: PF09335   
BioCyc: EcoCyc:EG11824-MONOMER    ECOL168927:B3009-MONOMER   
KEGG: ecj:JW2976    eco:b3009   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0043093 P:binary fission
GO:0000910 P:cytokinesis

References (4)

[1] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[2] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[3] “Evolution in biosynthetic pathways: two enzymes catalyzing consecutive steps in methionine biosynthesis originate from a common ancestor and possess a similar regulatory region.”  Belfaiza J.et.al.   3513164
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAVIQDIIAA LWQHDFAALA DPHIVSVVYF VMFATLFLEN GLLPASFLPG DSLLILAGAL 
61:	IAQGVMDFLP TIAILTAAAS LGCWLSYIQG RWLGNTKTVK GWLAQLPAKY HQRATCMFDR 
121:	HGLLALLAGR FLAFVRTLLP TMAGISGLPN RRFQFFNWLS GLLWVSVVTS FGYALSMIPF 
181:	VKRHEDQVMT FLMILPIALL TAGLLGTLFV VIKKKYCNA