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9.B.27.2.2
The YqjA protein is 60% identical to YghB, and these two act synergistically to maintain a normal pmf (Kumar and Doerrler 2015). Perhaps secondarily, when both YghB and YqjA are mutated, the cells exhibit a cell division defect (Thompkins et al., 2008). It has been proposed that YqjA possesses proton-dependent transport activity that is stimulated by osmolarity and that it plays a significant role in the survival of E. coli at alkaline pH, perhaps as an osmosensory cation-dependent proton transporter (a cation:proton antiporter?) (Kumar and Doerrler 2015).

Accession Number:P0AA63
Protein Name:YqjA
Length:220
Molecular Weight:24585.00
Species:Escherichia coli (strain K12). [83333]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Selenite, H+

Cross database links:

Genevestigator: P0AA63
EchoBASE: EB2596
EcoGene: EG12740
eggNOG: COG0586
HEGENOM: HBG657460
RefSeq: AP_003644.1    NP_417566.1   
Entrez Gene ID: 947643   
Pfam: PF09335   
BioCyc: EcoCyc:G7609-MONOMER    ECOL168927:B3095-MONOMER   
KEGG: ecj:JW3066    eco:b3095   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0043093 P:binary fission
GO:0000910 P:cytokinesis

References (3)

[1] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[2] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[3] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MELLTQLLQA LWAQDFETLA NPSMIGMLYF VLFVILFLEN GLLPAAFLPG DSLLVLVGVL 
61:	IAKGAMGYPQ TILLLTVAAS LGCWVSYIQG RWLGNTRTVQ NWLSHLPAHY HQRAHHLFHK 
121:	HGLSALLIGR FIAFVRTLLP TIAGLSGLNN ARFQFFNWMS GLLWVLILTT LGYMLGKTPV 
181:	FLKYEDQLMS CLMLLPVVLL VFGLAGSLVV LWKKKYGNRG