TCDB is operated by the Saier Lab Bioinformatics Group

9.B.299.  The Large Prokaryotic COG1615 (COG1615) Family 

Members of this family are numerous and larger (usually between 900 and 1100 aas) with 6 - 10 TMSs in their N-terminal region. The remainder of the proteins are hydrophilic. They are derived from bacteria and archaea.