TCDB is operated by the Saier Lab Bioinformatics Group

9.B.204.  The Prokaryotic 2 TMS domain Protein (Pr2TM) Family 

This family is widespread in bacteria and archaea.  The 2 TMS domain is referred to as 2TM with Pfam # 13239.  It may be involved in cell lysis or peptidoglycan turnover, and thus, could be a holin (TC subclass # 1.E).  Some of these proteins have a C-terminal MAS protein import receptor domain (Pfam # 02064).