9.B.34 The Kinase/Phosphatase/Cyclic-GMP Synthase/Cyclic di-GMP Hydrolase (KPSH) Family
The KPSH family, is a heterogeneous group of multidomain proteins, each exhibiting a different set of domain combinations, suggesting differing catalytic and regulatory functions. Catalytic domains in these proteins include kinases, phosphatases, cyclic di-GMP synthetases and cyclic di-GMP hydrolases (KPSH). None of the members of the KPSH family have been functionally characterized, but the sequence similarity with characterized proteins and protein domains allowed functional predictions with a high degree of confidence (Mansour et al., 2007). The N-terminal 'transporter' domain has not been shown to have transport activity.