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9.B.35.1.1
Transthyretin (prealbumin) precursor

Accession Number:P02767
Protein Name:TTHY aka TTR aka TT
Length:147
Molecular Weight:15720.00
Species:Rattus norvegicus (Rat) [10116]
Location1 / Topology2 / Orientation3: Secreted1
Substrate Unknown

Cross database links:

Genevestigator: P02767
eggNOG: roNOG16226
RefSeq: NP_036813.1   
Entrez Gene ID: 24856   
Pfam: PF00576   
KEGG: rno:24856   

Gene Ontology

GO:0005615 C:extracellular space
GO:0005179 F:hormone activity
GO:0042562 F:hormone binding
GO:0015349 F:thyroid hormone transmembrane transporter a...
GO:0042403 P:thyroid hormone metabolic process
GO:0006810 P:transport

References (10)

[1] “The primary structure of rabbit and rat prealbumin and a comparison with the tertiary structure of human prealbumin.”  Sundelin J.et.al.   3922975
[2] “Rat transthyretin (prealbumin). Molecular cloning, nucleotide sequence, and gene expression in liver and brain.”  Dickson P.W.et.al.   3839240
[3] “Cloning and nucleotide sequencing of transthyretin (prealbumin) cDNA from rat choroid plexus and liver.”  Duan W.et.al.   2734110
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Structure and expression of the rat transthyretin (prealbumin) gene.”  Fung W.-P.et.al.   2891699
[6] “Rat plasma prealbumin. Isolation and partial characterization.”  Navab M.et.al.   873934
[7] “Thyroxine transport from blood to brain via transthyretin synthesis in choroid plexus.”  Schreiber G.et.al.   2309926
[8] “Crystal structure of rat transthyretin at 2.5-A resolution: first report on a unique tetrameric structure.”  Wojtczak A.et.al.   9511961
[9] “Complex of rat transthyretin with tetraiodothyroacetic acid refined at 2.1 and 1.8 A resolution.”  Muziol T.et.al.   11995998
[10] “High-resolution molecular structure of a peptide in an amyloid fibril determined by magic angle spinning NMR spectroscopy.”  Jaroniec C.P.et.al.   14715898
Structure:
1GKE   1IE4   1KGI   1KGJ   1RVS   2M5K   2M5M   3ZPK     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MASLRLFLLC LAGLIFASEA GPGGAGESKC PLMVKVLDAV RGSPAVDVAV KVFKKTADGS 
61:	WEPFASGKTA ESGELHGLTT DEKFTEGVYR VELDTKSYWK ALGISPFHEY AEVVFTANDS 
121:	GHRHYTIAAL LSPYSYSTTA VVSNPQN