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9.B.38.1.3
Neuronal membrane glycoprotein M6-b (M6b) (Rhombencephalic expression protein-29 kDa) (Rhombex-29)

Accession Number:P35803
Protein Name:Neuronal membrane glycoprotein M6-b
Length:328
Molecular Weight:36210.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

Genevestigator: P35803
eggNOG: NOG300631
Entrez Gene ID: 14758   
Pfam: PF01275   
KEGG: mmu:14758   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0045121 C:membrane raft
GO:0005886 C:plasma membrane
GO:0085029 P:extracellular matrix assembly
GO:2000009 P:negative regulation of protein localization at cell surface
GO:0051612 P:negative regulation of serotonin uptake
GO:0001503 P:ossification
GO:0030501 P:positive regulation of bone mineralization
GO:0015031 P:protein transport
GO:0032956 P:regulation of actin cytoskeleton organization
GO:0051893 P:regulation of focal adhesion assembly

References (7)

[1] “Molecular cloning of M6: identification of a PLP/DM20 gene family.”  Yan Y.et.al.   8398137
[2] “Multiple splice isoforms of proteolipid M6B in neurons and oligodendrocytes.”  Werner H.et.al.   11749036
[3] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[4] “Lineage-specific biology revealed by a finished genome assembly of the mouse.”  Church D.M.et.al.   19468303
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.”  Munton R.P.et.al.   17114649
[7] “Membrane glycoprotein M6B interacts with the human serotonin transporter.”  Fjorback A.W.et.al.   18581270

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKPAMETAAE ENTEQSQERK VNSRAEMEIG RYHWMYPGSK NHQYRPVPNL GDRAGPLSSP 
61:	GCFECCIKCL GGVPYASLVA TILCFSGVAL FCGCGHVALA GTVAILEQHF STNTSDHALL 
121:	SEVIQLMQYV IYGIASFFFL YGIILLAEGF YTTSAVKELH GEFKTTACGR CISGMFVFLT 
181:	YVLGVAWLGV FGFSAVPVFM FYNIWSTCEV IKSPQSNGTS GVEQICVDVR QYGIIPWNAF 
241:	PGKICGSALE NICNTNEFYM SYHLFIVACA GAGATVIALI HFLMILSSNW AYLKDASKMQ 
301:	AYQDIKAKEE QELQDIQSRS KEQLNSYT