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9.B.39.1.1
CD36 antigen; plasma membrane fatty acid transporter (Schwenk et al. 2010). Also called the scavenger receptor protein as it binds many ligands including both Gram-positive and Gram-negative bacteria; plays a role in immune development (Liu et al. 2016). Direct interaction of CD36 with glycerol phospholipids has been demonstrated (Tsuzuki et al. 2017). CD36 plays a role in the perception of specific odour-active volatile compounds including oleic aldehyde (cis-9-octadecenal), in the nasal cavity (Lee et al. 2017).

Accession Number:Q08857
Protein Name:CD36
Length:472
Molecular Weight:52698.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate fatty acids

Cross database links:

Genevestigator: Q08857
eggNOG: roNOG12579
HEGENOM: HBG445256
RefSeq: NP_001153027.1    NP_001153028.1    NP_001153029.1    NP_001153030.1    NP_031669.3   
Entrez Gene ID: 12491   
Pfam: PF01130   
KEGG: mmu:12491   

Gene Ontology

GO:0009897 C:external side of plasma membrane
GO:0005794 C:Golgi apparatus
GO:0016021 C:integral to membrane
GO:0045121 C:membrane raft
GO:0051636 F:Gram-negative bacterial cell surface binding
GO:0051637 F:Gram-positive bacterial cell surface binding
GO:0008035 F:high-density lipoprotein binding
GO:0008289 F:lipid binding
GO:0070892 F:lipoteichoic acid receptor activity
GO:0005041 F:low-density lipoprotein receptor activity
GO:0043277 P:apoptotic cell clearance
GO:0007155 P:cell adhesion
GO:0071221 P:cellular response to bacterial lipopeptide
GO:0071222 P:cellular response to lipopolysaccharide
GO:0071223 P:cellular response to lipoteichoic acid
GO:0030301 P:cholesterol transport
GO:0050830 P:defense response to Gram-positive bacterium
GO:0019915 P:lipid storage
GO:0042159 P:lipoprotein catabolic process
GO:0034381 P:lipoprotein particle clearance
GO:0042953 P:lipoprotein transport
GO:0044130 P:negative regulation of growth of symbiont i...
GO:0006910 P:phagocytosis, recognition
GO:0010886 P:positive regulation of cholesterol storage
GO:0043123 P:positive regulation of I-kappaB kinase/NF-k...
GO:0032735 P:positive regulation of interleukin-12 produ...
GO:0032755 P:positive regulation of interleukin-6 produc...
GO:0060907 P:positive regulation of macrophage cytokine ...
GO:0010744 P:positive regulation of macrophage derived f...
GO:0043410 P:positive regulation of MAPKKK cascade
GO:0060100 P:positive regulation of phagocytosis, engulf...
GO:0032760 P:positive regulation of tumor necrosis facto...

References (2)

[1] “CD36 is a receptor for oxidized low density lipoprotein.”  Endemann G.et.al.   7685021
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MGCDRNCGLI AGAVIGAVLA VFGGILMPVG DMLIEKTIKR EVVLEEGTTA FKNWVKTGTT 
61:	VYRQFWIFDV QNPDDVAKNS SKIKVKQRGP YTYRVRYLAK ENITQDPEDH TVSFVQPNGA 
121:	IFEPSLSVGT EDDNFTVLNL AVAAAPHIYQ NSFVQVVLNS LIKKSKSSMF QTRSLKELLW 
181:	GYKDPFLSLV PYPISTTVGV FYPYNDTVDG VYKVFNGKDN ISKVAIIESY KGKRNLSYWP 
241:	SYCDMINGTD AASFPPFVEK SRTLRFFSSD ICRSIYAVFG SEIDLKGIPV YRFVLPANAF 
301:	ASPLQNPDNH CFCTEKVISN NCTSYGVLDI GKCKEGKPVY ISLPHFLHAS PDVSEPIEGL 
361:	HPNEDEHRTY LDVEPITGFT LQFAKRLQVN ILVKPARKIE ALKNLKRPYI VPILWLNETG 
421:	TIGDEKAEMF KTQVTGKIKL LGMVEMALLG IGVVMFVAFM ISYCACKSKN GK