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9.B.39.1.3
Scavenger receptor class B, member 1 (SR-B1; SCARB1; CD3621; CLA1). It comprises the hepatits C receptor together with its co-receptor, CD81 tetraspanin (Bartosch et al., 2003). When defective, leads to antibody deficiency. SR-B1 is a receptor for different ligands such as phospholipids, cholesterol esters, lipoproteins, phosphatidylserine and apoptotic cells. It facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as high density lipoproteins (HDL) and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins (Orlowski et al. 2007). It is necessary for selective HDL-cholesterol uptake (Zanoni et al. 2016). Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity.  Several proteins have been implicated in fatty acid transport by enterocytes including the scavenger receptor CD36 (SR-B2), the scavenger receptor B1 (SR-B1), and the FA transport protein 4 (FATP4) (Cifarelli and Abumrad 2018).

Accession Number:Q8WTV0
Protein Name:Scavenger receptor class B member 1
Length:552
Molecular Weight:60878.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate phospholipids, Cholesterol Esters, Lipoproteins, phosphatidylserine, Apoptotic cells

Cross database links:

Genevestigator: Q8WTV0
eggNOG: prNOG09209
Entrez Gene ID: 949   
Pfam: PF01130   
Drugbank: Drugbank Link   
KEGG: hsa:949   

Gene Ontology

GO:0005901 C:caveola
GO:0005545 F:1-phosphatidylinositol binding
GO:0034186 F:apolipoprotein A-I binding
GO:0070506 F:high-density lipoprotein particle receptor activity
GO:0001875 F:lipopolysaccharide receptor activity
GO:0030169 F:low-density lipoprotein particle binding
GO:0001786 F:phosphatidylserine binding
GO:0005215 F:transporter activity
GO:0051856 P:adhesion to symbiont
GO:0007155 P:cell adhesion
GO:0033344 P:cholesterol efflux
GO:0042632 P:cholesterol homeostasis
GO:0070508 P:cholesterol import
GO:0032497 P:detection of lipopolysaccharide
GO:0034384 P:high-density lipoprotein particle clearance
GO:0034375 P:high-density lipoprotein particle remodeling
GO:0015920 P:lipopolysaccharide transport
GO:0042157 P:lipoprotein metabolic process
GO:0010886 P:positive regulation of cholesterol storage
GO:0010595 P:positive regulation of endothelial cell migration
GO:0051000 P:positive regulation of nitric-oxide synthase activity
GO:0043654 P:recognition of apoptotic cell
GO:0050764 P:regulation of phagocytosis
GO:0043691 P:reverse cholesterol transport
GO:0070328 P:triglyceride homeostasis
GO:0042060 P:wound healing

References (10)

[1] “Identification, primary structure and distribution of CLA-1, a novel member of the CD36/LIMPII gene family.”  Calvo D.et.al.   7689561
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus.”  Scarselli E.et.al.   12356718
[4] “Phosphatidylserine binding of class B scavenger receptor type I, a phagocytosis receptor of testicular Sertoli cells.”  Kawasaki Y.et.al.   12016218
[5] “Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor.”  Bartosch B.et.al.   12913001
[6] “Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.”  Chen R.et.al.   19159218
[7] “Biological, clinical and population relevance of 95 loci for blood lipids.”  Teslovich T.M.et.al.   20686565
[8] “Polymorphisms at the SRBI locus are associated with lipoprotein levels in subjects with heterozygous familial hypercholesterolemia.”  Tai E.S.et.al.   12519372
[9] “Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors.”  Morabia A.et.al.   12966036
[10] “Genetic variant of the scavenger receptor BI in humans.”  Vergeer M.et.al.   21226579

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGCSAKARWA AGALGVAGLL CAVLGAVMIV MVPSLIKQQV LKNVRIDPSS LSFNMWKEIP 
61:	IPFYLSVYFF DVMNPSEILK GEKPQVRERG PYVYREFRHK SNITFNNNDT VSFLEYRTFQ 
121:	FQPSKSHGSE SDYIVMPNIL VLGAAVMMEN KPMTLKLIMT LAFTTLGERA FMNRTVGEIM 
181:	WGYKDPLVNL INKYFPGMFP FKDKFGLFAE LNNSDSGLFT VFTGVQNISR IHLVDKWNGL 
241:	SKVDFWHSDQ CNMINGTSGQ MWPPFMTPES SLEFYSPEAC RSMKLMYKES GVFEGIPTYR 
301:	FVAPKTLFAN GSIYPPNEGF CPCLESGIQN VSTCRFSAPL FLSHPHFLNA DPVLAEAVTG 
361:	LHPNQEAHSL FLDIHPVTGI PMNCSVKLQL SLYMKSVAGI GQTGKIEPVV LPLLWFAESG 
421:	AMEGETLHTF YTQLVLMPKV MHYAQYVLLA LGCVLLLVPV ICQIRSQVGA GQRAARADSH 
481:	SLACWGKGAS DRTLWPTAAW SPPPAAVLRL CRSGSGHCWG LRSTLASFAC RVATTLPVLE 
541:	GLGPSLGGGT GS