TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*9.B.64.1.1









The metastatic lymph node-64 (MLN-64; MLN64; STARD3; CAB1) protein mediates endosomal cholesterol transport to mitochondria and the plasma membrane (Kennedy et al. 2014). It has been implicated in toxin-induced resistance. Down-regulation of MLN64 in Niemann-Pick C1 deficient cells decreased mitochondrial cholesterol content, suggesting that MLN64 functions independently of NPC1 (Balboa et al. 2017), and overexpression increases the mitochondrial cholesterol content and decreases the mitochondrial glutathione content, leading to mitochondrial dysfunction (Balboa et al. 2017).

Eukaryota
Metazoa
MLN-64 of Homo sapiens (Q14849)
*9.B.64.1.2









The Start1 protein (putative cholesterol transporter)
Eukaryota
Metazoa
Start1 protein of Drosophila melanogaster (AAR19767)