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9.B.67 The O-antigen Polymerase (OAP) Family

The O-antigen polymerase (ligase) family (COG3307) consists of proteins of this function. It is probable that O-antigen polymerases facilitate export of intermediates of LPS biosynthesis. Several of the proteins listed in this table are distantly related to each other, but homology has been established (DE Chen and MH Saier, unpublished results). This family may be distantly related to 9.B.128, also designated as an O-antigen polymerase family. A homologue designated ictB or ORF467 in Synechococcus sp. strain PCC7942 was reprted to be a Na+:HCO3- symporter, but this conclusion may have been in error.

 The probable transport reaction proposed for OAP family members is:

O-antigen precursor (in) → O-antigen precursor (out).

This family belongs to the: O-Antigen Polymerase (OAPol) Superfamily.

References associated with 9.B.67 family:

Bonfil, D.J., M. Ronen-Tarazi, D. Sültemeyer, J. Lieman-Hurwitz, D. Schatz, and A. Kaplan. (1998). A putative HCO3- transporter in the cyanobacterium Synechococcus sp. strain PCC7942. FEBS Lett. 430: 236-240. 9688546
Pan, Y., X. Ruan, M.A. Valvano, and L. Konermann. (2012). Validation of membrane protein topology models by oxidative labeling and mass spectrometry. J Am Soc Mass Spectrom 23: 889-898. 22410873
Schild, S., A.K. Lamprecht, and J. Reidl. (2005). Molecular and functional characterization of O antigen transfer in Vibrio cholerae. J. Biol. Chem. 280: 25936-25947. 15908430
Tyrrell, P.N., R.A. Kandasamy, C.M. Crotty, and G.S. Espie. (1996). Ethoxyzolamide differentially inhibits CO2 uptake and Na+-independent and Na+-dependent HCO3- uptake in the cyanobacterium Synechococcus sp. UTEX 625. Plant Physiol. 112: 79-88. 12226376