9.B.68 The Putative Na-independent Organic Solute Carrier Protein (OSCP1) Family
Kobayashi et al. (2005) reported the isolation of a novel organic solute carrier from a human placenta cDNA library. The 379 aas protein has an N-terminal hydrophobic peak but otherwise appears hydrophilic. When expressed in Xenopus laevis oocytes, high-affinity transport of PAH and TEA (see below) was observed. Because of its hydrophilic nature, it seems possible that it stimulated uptake via endogenous frog transporters.