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9.B.68 The Putative Na-independent Organic Solute Carrier Protein (OSCP1) Family

Kobayashi et al. (2005) reported the isolation of a novel organic solute carrier from a human placenta cDNA library. The 379 aas protein has an N-terminal hydrophobic peak but otherwise appears hydrophilic. When expressed in Xenopus laevis oocytes, high-affinity transport of PAH and TEA (see below) was observed. Because of its hydrophilic nature, it seems possible that it stimulated uptake via endogenous frog transporters.

References associated with 9.B.68 family:

Kobayashi, Y., A. Shibusawa, H. Saito, N. Ohshiro, M. Ohbayashi, N. Kohyama, and T. Yamamoto. (2005). Isolation and functional characterization of a novel organic solute carrier protein, hOSCP1. J. Biol. Chem. 280: 32332-32339. 16006562