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9.B.68.1.1
The putative Na+-independent organic solute transporter (takes up or stimulates uptake of p-amino hippurate (PAH) (Km = 35.0 µM), tetraethylammonium (Km = 62 µM) and other organic solutes in frog oocytes). The protein exhibits one N-terminal TMS but is otherwise hydrophilic (Kobayashi et al., 2005).

Accession Number:Q8WVF1
Protein Name:OSCP1
Length:379
Molecular Weight:43271.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Basal cell membrane1
Substrate Organic solutes, p-aminohippurate, Tetraethylammonium

Cross database links:

Genevestigator: Q8WVF1
eggNOG: prNOG06607
RefSeq: NP_659484.4   
Entrez Gene ID: 127700   
Pfam: PF10188   
OMIM: 608854  gene
KEGG: hsa:127700   

Gene Ontology

GO:0009925 C:basal plasma membrane
GO:0006810 P:transport

References (5)

[1] “Cloning, expression, and mutation analysis of NOR1, a novel human gene down-regulated in HNE-1 nasopharyngeal carcinoma cell line.”  Nie X.et.al.   12819961
[2] “Isolation and functional characterization of a novel organic solute carrier protein, hOSCP1.”  Kobayashi Y.et.al.   16006562
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSVRTLPLLF LNLGGEMLYI LDQRLRAQNI PGDKARKVLN DIISTMFNRK FMEELFKPQE 
61:	LYSKKALRTV YERLAHASIM KLNQASMDKL YDLMTMAFKY QVLLCPRPKD VLLVTFNHLD 
121:	TIKGFIRDSP TILQQVDETL RQLTEIYGGL SAGEFQLIRQ TLLIFFQDLH IRVSMFLKDK 
181:	VQNNNGRFVL PVSGPVPWGT EVPGLIRMFN NKGEEVKRIE FKHGGNYVPA PKEGSFELYG 
241:	DRVLKLGTNM YSVNQPVETH VSGSSKNLAS WTQESIAPNP LAKEELNFLA RLMGGMEIKK 
301:	PSGPEPGFRL NLFTTDEEEE QAALTRPEEL SYEVINIQAT QDQQRSEELA RIMGEFEITE 
361:	QPRLSTSKGD DLLAMMDEL