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9.B.73.1.2
Putative transporter involved in H+ extrusion and indirectly CO2 uptake, CotA. The 3 TMS hydrophobic domain belongs to the CDD CemA family. CotA may be a heme binding protein (Katoh et al., 1996).

Accession Number:P75028
Protein Name:PcxA aka CotA aka slr1596
Length:440
Molecular Weight:51117.00
Species:Synechocystis sp. (strain PCC 6803) [1148]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate H+, CO2

Cross database links:

eggNOG: NOG06592
HEGENOM: HBG439473
RefSeq: NP_440313.1   
Entrez Gene ID: 953612   
Pfam: PF03040   
BioCyc: SSP1148:SLR1596-MONOMER   
KEGG: syn:slr1596   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015078 F:hydrogen ion transmembrane transporter acti...
GO:0015992 P:proton transport

References (5)

[1] “cemA homologue essential to CO2 transport in the cyanobacterium Synechocystis PCC6803.”  Katoh A.et.al.   8633006
[2] “Size of cotA and identification of the gene product in Synechocystis sp. strain PCC6803.”  Sonoda M.et.al.   9190798
[3] “Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions.”  Kaneko T.et.al.   8905231
[4] “Absence of light-induced proton extrusion in a cotA-less mutant of Synechocystis sp. strain PCC6803.”  Katoh A.et.al.   8808935
[5] “Photosynthetic electron transport involved in PxcA-dependent proton extrusion in Synechocystis sp. Strain PCC6803: effect of pxcA inactivation on CO2, HCO3-, and NO3- uptake.”  Sonoda M.et.al.   9683474

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MDLTNWWQGA TQWFGRSSQK SLEQAFRSAL KIKEIEDQYF QGKKIGPENC DYSADTVTYF 
61:	ANQIQRHLRK IEQEIYHLNS DQEFVKILSL DPAVKQDPQT EYVLNQLQFI DDILQRYDGE 
121:	LPQVSPPKQI ANGGVLDLPA ITANKQRQIN KKRRDGFQYI RREDTQQKVD TATQKSGVLP 
181:	RSFLRTIDRL KREMDPQSSD TEQKVLKQYR NSRYKTALSI KFVLTLIIVP LLAHQLTKTF 
241:	FLLPSVESFF ERNSEVVFIN QSMETEAYEE LSHFEESLRF RELLGFGEKL SPEAKEEKLA 
301:	EKAKEISESY RRVSTNAIAN IFADIFSLVA FSLVLVNSQR EIEVLKEFID EIVYGLSDSA 
361:	KAFLIILFTD MFVGFHSPHG WEVILASIAR HFGLPENQDF NFLFIATFPV ILDTVFKYWI 
421:	FRYLNSISPS AVATYRNMNE