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9.B.82 The  Endoplasmic Reticulum Retrieval Protein1 (Putative Heavy Metal Transporter) (Rer1) Family

Mutations in the gene encoding the 4 TMS (2 + 2) Rer1 protein in S. cerevisiae (of about 190 aas as are most of its homologues) can be complemented by human NRAMP1 (TC# 2.A.55.2.3), suggesting that it might be a heavy metal efflux pump (Techau et al., 2007). It has homologues in many fungi, animals, plants and other eukaryotes, almost all of about 190 aas. Single oraganisms can have multiple paralogues.

References associated with 9.B.82 family:

Techau, M.E., J. Valdez-Taubas, J.F. Popoff, R. Francis, M. Seaman, and J.M. Blackwell. (2007). Evolution of differences in transport function in slc11a family members. J. Biol. Chem. 282: 35646-35656. 17932044