TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*9.B.87.1.1









Low density lipoprotein receptor-related protein 2 precursor (Megalin - 4660aas; glycoprotein 330) [required for SelP uptake in kidney]. May take up cadmium-metallothionein complexes via receptor-mediated endocytosis (Thévenod, 2010).

Eukaryota
Metazoa
Megalin of Mus musculus (A2ARV4)
*9.B.87.1.2









The EGF-like domain-containing protein of 1918 aas.

Eukaryota
Dictyosteliida
EGF-like domain protein of Dictyostelium discoideum
*9.B.87.1.3









Uncharacterized protein of 270 aas.

Eukaryota
Viridiplantae
UP of Chlorella variabilis (Green alga)
*9.B.87.1.4









Viruses
Poxviridae
EGF-like protein of Variola (smallpox) virus
*9.B.87.1.5









Uncharacterized protein of 3499 aas and 2 TMSs.

Eukaryota
Metazoa
UP of Tetraodon nigroviridis
*9.B.87.1.6









Uncharacterized protein of 628 aas and 2 TMSs

Eukaryota
Viridiplantae
UP of Picea sitchensis
*9.B.87.1.7









Putative vacuolar sorting receptor protein homologue of 631 aas and 2 TMSs

Eukaryota
Viridiplantae
Vacuolar sorting receptor of Oryza sativa
*9.B.87.1.8









Integrin β-1 of 798 aas and 2 TMSs, N- and C-termini.

Eukaryota
Metazoa
ITGB1 of Homo sapiens
*9.B.87.1.9









Low density lipoprotein receptor, Apolipoprotein E receptor 2 (ApoER2; 996aas) [required for SelP uptake in brain and testis, but not kidney].
Eukaryota
Metazoa
ApoER2 of Mus musculus (Q924X6)
*9.B.87.1.10









Lipophorin receptor of 881 aas, LpR2 (Tufail and Takeda 2009).

Eukaryota
Metazoa
LpR2 of Bombyx mori
*9.B.87.1.11









Crumbs, Crb of 2146 aas and 2 TMSs at the N- and C-termini.  Plays a central role in cell polarity establishment. Participates in the assembly, positioning and maintenance of adherens junctions via its interaction with the SAC complex. Controls the coalescence of the spots of zonula adherens (ZA) into a adhesive ring around the cells (Tepass et al. 1990).

Eukaryota
Metazoa
Crumbs of Drosophila melanogaster
*9.B.87.1.12









Neurogenic locus Notch homolog protein 1, NOTCH of 2,555 aas and 2 TMSs, one N-terminal and one nearer the C-terminus.  Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD), it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs (Brütsch et al. 2010). NOTCH is a schizophrenia gene (Sundararajan et al. 2018). The NOTCH1 signalling pathway regulates vascular barrier function, driving assembly of adherens junction and vascular barrier functions (Polacheck et al. 2017).

 

Eukaryota
Metazoa
*9.B.87.1.13









The BP80 vacuolar sorting receptor of 623 aas and two (N- and C-terminal) TMSs (daSilva et al. 2006). BP80 is a vacuolar sorting receptor for soluble proteins and has a cytosolic domain essential for its intracellular trafficking between the trans-Golgi network and the prevacuole (Saint-Jean et al. 2010).

Eukaryota
Viridiplantae
BP80 of Arabidopsis thaliana (Mouse-ear cress)
*9.B.87.1.14









Low-density lipoprotein receptor-related protein 2, LRP2, of 4630 aas and 1 TMS. Also called the multiligand endocytic receptor. Acts together with CUBN to mediate endocytosis of high-density lipoproteins and is responsible for receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B. In the kidney, it mediates the tubular uptake and clearance of leptin, and transports leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium. Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight. It also mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells, and catalyzes renal uptake of 25-hydroxyvitamin D3 in complex with the vitamin D3 transporter GC/DBP. It is also involved in the renal uptake of metallothionein-bound heavy metals (Klassen et al. 2004). Together with CUBN, it mediates renal reabsorption of myoglobin as well as renal uptake and subsequent lysosomal degradation of APOM while playing a role in kidney selenium homeostasis by facilitating renal endocytosis of selenoprotein SEPP1. It similarly mediates renal uptake of the antiapoptotic protein BIRC5/survivin which may be important for functional integrity of the kidney (Jobst-Schwan et al. 2013).

Eukaryota
Metazoa
LRP2 of Homo sapiens
*9.B.87.1.15









CFEM domain containing protein of 464 aas and possibly 2 TMSs, N- and C-terminal.

Eukaryota
Fungi
CFEM containing protein of Beauveria bassiana (White muscardine disease fungus) (Tritirachium shiotae)
*9.B.87.1.16









Pro-low-density lipoprotein receptor-related protein 1, pro-LRP1, of 4544 aas and 2 TMSs, one at the N-terminus, and one near the C-terminus.  It is an endocytic receptor involved in endocytosis, in phagocytosis of apoptotic cells, in early embryonic development, and in cellular lipid homeostasis. It may modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (May et al. 2002, Kinoshita et al. 2003, May and Herz 2003). It acts as an alpha-2-macroglobulin receptor (Klar et al. 2015).and serves as a receptor for Pseudomonas aeruginosa exotoxin A (Kounnas et al. 1992). It modulates APP transport and processing (Eggert et al. 2018).

 

Eukaryota
Metazoa
por-LUP1 of Homo sapiens
*9.B.87.1.17









Sortilin-related protein, SorL1 or SorLA, of 2214 aas and 2 TMSs, N- and C-terminal.  It is a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. It also binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis (Andersen et al. 2005). This protein contains a large domain that is homologous to several proteins in TC family 9.A.63.

Eukaryota
Metazoa
SorLA of Homo sapiens
*9.B.87.1.18









SPO-spondin of 5150 aas.  It is involved in the modulation of neuronal aggregation and may be involved in developmental events during the formation of the central nervous system.

Eukaryota
Metazoa
SPO-spondin of Homo sapiens
*9.B.87.2.1









Astrotactin-1, Astn1, of 1174 aas with a MACPF domain.  It is a neuronal adhesion molecule that is required for glial-guided migration of young postmitotic neuroblasts in cortical regions of the developing brain, including the cerebrum, hippocampus, cerebellum and olfactory bulb. Functions in proliferation and migration of Schwann cells (Yi et al. 2016).

Eukaryota
Metazoa
Astrotactin-1 of Homo sapiens