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9.B.87.1.9
Low density lipoprotein receptor, Apolipoprotein E receptor 2 (ApoER2; 996aas) [required for SelP uptake in brain and testis, but not kidney].

Accession Number:Q924X6
Protein Name:ApoER2
Length:996
Molecular Weight:109818.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell membrane1 / Single-pass type I membrane protein2
Substrate SelP

Cross database links:

Genevestigator: Q924X6
eggNOG: roNOG08019
HEGENOM: HBG358235
RefSeq: NP_001074395.1    NP_444303.2   
Entrez Gene ID: 16975   
Pfam: PF07645    PF00057    PF00058   
KEGG: mmu:16975   

Gene Ontology

GO:0005615 C:extracellular space
GO:0016021 C:integral to membrane
GO:0005509 F:calcium ion binding
GO:0005041 F:low-density lipoprotein receptor activity
GO:0006897 P:endocytosis
GO:0021766 P:hippocampus development
GO:0021819 P:layer formation in the cerebral cortex
GO:0045860 P:positive regulation of protein kinase activity

References (9)

[1] “Evolution of the apolipoprotein E receptor 2 gene by exon loss.”  Kim H.-J.et.al.   9685741
[2] “Alternative splicing in the ligand binding domain of mouse ApoE receptor-2 produces receptor variants binding reelin but not alpha2-macroglobulin.”  Brandes C.et.al.   11294845
[3] “The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor.”  Stockinger W.et.al.   12169628
[4] “Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase.”  May P.et.al.   12871934
[5] “A secreted soluble form of ApoE receptor 2 acts as a dominant-negative receptor and inhibits Reelin signaling.”  Koch S.et.al.   12426372
[6] “Essential role of the apolipoprotein E receptor-2 in sperm development.”  Andersen O.M.et.al.   12695510
[7] “Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.”  Trommsdorff M.et.al.   10380922
[8] “The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2.”  Stockinger W.et.al.   10827199
[9] “Differential binding of ligands to the apolipoprotein E receptor 2.”  Andersen O.M.et.al.   12899622

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGRPELGALR PLALLLLLLL QLQHLSAADP LPGGQGPVKE CEEDQFRCRN ERCIPLVWRC 
61:	DEDNDCSDNS DEDDCPKRTC ADSDFTCDNG HCIPERWKCD GEEECPDGSD ESKATCSSEE 
121:	CPAEKLSCGP TSHKCVPASW RCDGEKDCEG GADEAGCPTL CAPHEFQCSN RSCLASVFVC 
181:	DGDDDCGDGS DERGCSDPAC PPREFRCGGG GTCIPERWVC DRQFDCEDRS DEAAELCGRA 
241:	GQGTTATPAA CAPTAQFTCR SGECIHLGWR CDGDRDCKDK SDEADCSPGP CRENEFQCGD 
301:	GTCVLAIKRC NQERDCPDGS DEAGCLQEST CEGPRRFQCK SGECVDGGKV CDDQRDCRDW 
361:	SDEPQKVCGL NECLHNNGGC SHICTDLKIG FECTCPAGFQ LLDQKTCGDI DECQDPDACS 
421:	QICVNYKGYF KCECHPGYEM DTLTKNCKAV AGKSPSLIFT NRHEVRRIDL VKRDYSRLIP 
481:	MLKNVVALDV EVATNRIYWC DLSYRKIYSA HMDKASIPDE QVVLIDEQLH SPEGLAVDWV 
541:	HKHIYWTDSG NKTISVATTD GRRRCTLFSR ELSEPRAIAV DPLRGFMYWS DWGFQAKIEK 
601:	AGLNGADRQT LVSDNIEWPN GITLDLLSQR LYWVDSKLHQ LSSIDFNGGN RKMLIFSTDF 
661:	LSHPFGVAVF EDKVFWTDLE NEAIFSANRL NGLEIAILAE NLNNPHDIVI FHELKQPKAA 
721:	DACDLSAQPN GGCEYLCLPA PQISSHSPKY TCACPDTMWL GPDMKRCYRA PQSTSTTTLA 
781:	SAMTRTVPAT TRAPGTTIHD PTYQNHSTET PSQTAAAPHS VNVPRAPSTS PSTPSPATSN 
841:	HSQHYGNEGS QMGSTVTAAV IGVIVPIVVI ALLCMSGYLI WRNWKRKNTK SMNFDNPVYR 
901:	KTTEEEEEDE LHIGRTAQIG HVYPAAISNY DRPLWAEPCL GETRDLEDPA PALKELFVLP 
961:	GEPRSQLHQL PKNPLSELPV VKCKRVALSL EDDGLP