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9.B.88.2.1
Vascular endothelial growth factor, VEGF (419aas)

Accession Number:P49767
Protein Name:VEGF
Length:419
Molecular Weight:46883.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Secreted1
Substrate Unknown

Cross database links:

Genevestigator: P49767
eggNOG: prNOG04811
HEGENOM: HBG715596
DIP: DIP-5747N
RefSeq: NP_005420.1   
Entrez Gene ID: 7424   
Pfam: PF00341   
OMIM: 601528  gene
KEGG: hsa:7424   

Gene Ontology

GO:0016020 C:membrane
GO:0031093 C:platelet alpha granule lumen
GO:0008083 F:growth factor activity
GO:0001525 P:angiogenesis
GO:0051781 P:positive regulation of cell division
GO:0007165 P:signal transduction
GO:0006929 P:substrate-bound cell migration

References (9)

[1] “A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.”  Joukov V.et.al.   8617204
[2] “”  Joukov V.et.al.   8612600
[3] “Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4.”  Lee J.et.al.   8700872
[4] “Characterization of murine Flt4 ligand/VEGF-C.”  Fitz L.J.et.al.   9247316
[5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[6] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “Proteolytic processing regulates receptor specificity and activity of VEGF-C.”  Joukov V.et.al.   9233800
[9] “Signal peptide prediction based on analysis of experimentally verified cleavage sites.”  Zhang Z.et.al.   15340161
Structure:
2X1W   2X1X   4BSK     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MHLLGFFSVA CSLLAAALLP GPREAPAAAA AFESGLDLSD AEPDAGEATA YASKDLEEQL 
61:	RSVSSVDELM TVLYPEYWKM YKCQLRKGGW QHNREQANLN SRTEETIKFA AAHYNTEILK 
121:	SIDNEWRKTQ CMPREVCIDV GKEFGVATNT FFKPPCVSVY RCGGCCNSEG LQCMNTSTSY 
181:	LSKTLFEITV PLSQGPKPVT ISFANHTSCR CMSKLDVYRQ VHSIIRRSLP ATLPQCQAAN 
241:	KTCPTNYMWN NHICRCLAQE DFMFSSDAGD DSTDGFHDIC GPNKELDEET CQCVCRAGLR 
301:	PASCGPHKEL DRNSCQCVCK NKLFPSQCGA NREFDENTCQ CVCKRTCPRN QPLNPGKCAC 
361:	ECTESPQKCL LKGKKFHHQT CSCYRRPCTN RQKACEPGFS YSEEVCRCVP SYWKRPQMS