9.B.89 The Putative Channel-forming 3 TMSs MamF (MamF) Family
Most homologues initially brought up in PSI-BLAST searches with MamF as the query sequence are of 102-122 aas long with 3TMSs. They are found in a range of bacteria, archaea, and eukaryotes. More distant members are larger. For example, a hypothetical protein of the fungus, Chaetomium globosum (XP_001223682), is 246 with 3 C-terminal TMSs and a hydrophilic N-terminus. Another fungal protein of 453aas of Cryptococcus neoformans has an N-terminal 3 TMSs followed by a 4th TMSs and a long hydrophilic region. These proteins may play a role in iron transport (Scheffel et al., 2008).