TCDB is operated by the Saier Lab Bioinformatics Group

9.B.92 The Folate Receptor (FR) Family

Folate receptor proteins have been implicated in folate transport (Yasuda et al., 2008). They are homologous to riboflavin binding proteins (e.g., BAA08709). FRα of humans is 257 aas long with N- and C-terminal TMSs. Retbindins (EDC10974; 247aas) are also in this family.

References associated with 9.B.92 family:

Foraker, A.B., C.M. Khantwal, and P.W. Swaan. (2003). Current perspectives on the cellular uptake and trafficking of riboflavin. Adv Drug Deliv Rev 55: 1467-1483. 14597141
Jones, S.K., A. Sarkar, D.P. Feldmann, P. Hoffmann, and O.M. Merkel. (2017). Revisiting the value of competition assays in folate receptor-mediated drug delivery. Biomaterials 138: 35-45. 28551461
Kelley, R.A., M.R. Al-Ubaidi, and M.I. Naash. (2015). Retbindin is an extracellular riboflavin-binding protein found at the photoreceptor/retinal pigment epithelium interface. J. Biol. Chem. 290: 5041-5052. 25542898
Sabetian, S., M.S. Shamsir, and M. Abu Naser. (2014). Functional features and protein network of human sperm-egg interaction. Syst Biol Reprod Med 60: 329-337. 25222562
White, H.B., 3rd and A.H. Merrill, Jr. (1988). Riboflavin-binding proteins. Annu. Rev. Nutr. 8: 279-299. 3060168
Yasuda, S., S. Hasui, M. Kobayashi, S. Itagaki, T. Hirano, and K. Iseki. (2008). The mechanism of carrier-mediated transport of folates in BeWo cells: the involvement of heme carrier protein 1 in placental folate transport. Biosci. Biotechnol. Biochem. 72: 329-334. 18256483