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9.B.97.2.3
Acyl transferase of 822 aas and 14 putative TMSs.  Has an N-terminal TMS followed bya hydrophilic domain of about 270 aas which may include TMSs, followed by about 13 TMSs.  Plays a role in the uptake of a range of molecules including lipids and xenobiotic compounds from the intestine to surrounding tissues. Mediates transport of lipids from the intestine to the reproductive tract. Required for efficient yolk transport into oocytes. Vital for embryonic development (Brejning et al. 2014).  Mutants in the nrf-6 gene have extended lifespans and increased stress resistance (Brejning et al. 2014).

Accession Number:Q09225
Protein Name:Nose resistant to fluoxetine protein 6
Length:822
Molecular Weight:94206.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate lipids

Cross database links:

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  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGNMRRLLIF AVLVILTVIS NSKSSYKYDG SLFSSKELDY DETDTKAMGS VFSRYMSDSD 
61:	AQLILDLDFF RHFFNYAEAY RDGAEEGNLE LMKYAVEMVE KLKSFDISMA CVGDMMHLAW 
121:	TGVEYATHVE EHKNCSDCKC TPLFQQKKSE RHWIFNVFDA MGKVPAGIMS GNNLWVGSWS 
181:	TCRKIDVVKN AQGQKWKGQY CLATIDAYER DNPLVYFGNM MSGPPDKHCY DKTVKNVTDD 
241:	GFCFALFPVL KFGVCMPNTC TNHDVKQMLS FAIRATEGAV GTKSVCNVDV ECRAESYSDA 
301:	MSENGLAMFA LYLLIATVVL VTFGTLYDLF IVSKAPQDEK NSSAFNHPFI KFILAFSMYT 
361:	NGSEILQSKK NDREINSLHG VRFLSMCWII LGHTYYYIGT SLTTDNLVPT LINFPKQFHT 
421:	QIIVQAPLAV DSFFFLSGML AAFSFFKKTM KADPNHPPKL SAFNWQTWPM YYYKRYIRIT 
481:	PTYIIVMLFD VTLFTYISNG PFWRPIERQG CSIAWWTNLI YLNNFLLQDQ ECCMGWTWYL 
541:	ANDMQFHIFL MPLLVIVFLK WGMKVGLGLS TGLIALSSLI RLIITQIYGY PPAPILTAKL 
601:	QIVYQLNDYW NDVYVRPYIR CTPFIVGIVV AYLLNAWTTR EQKDLKIKLE RRTVIICWCT 
661:	STVLGLYSVF GLYWFAKTGD ISKPWEILYT IFGTPAYALA LGWVVFACTT GNGGPVDTIL 
721:	SWRLFVPLSK ITFCAYLLHP IMLQIYNLSR PQPFHFTTFI QMIRYTVEAV FASYTIAFFF 
781:	SLAFEKPLNK IDEMLFNSKK MMNGENGNTT EMVPLNKIRN SD