TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*9.B.97.1.1









YiaH 10 (5+5?) TMS transmembrane protein (331aas) (The O-acetyltransferase of enterobacterial common antigen (ECA). Exhibits some similarity with TC# 2.A.36.1.7)

Bacteria
Proteobacteria
YiaH of E. coli K12 (P37669)
*9.B.97.1.2









Phage putative 10 TMS, O157 antigen acylating, O-acetyltransferase, Oac. Acetylation blocks superinfection (Perry et al., 2009).

Viruses
Caudovirales
O-antigen transferase, Oac, of E. coli O157 phage ΦV10. (Q286Z2)
*9.B.97.1.3









The archaeal protein, Msp1344 (10TMSs)

Archaea
Euryarchaeota
Hypthetical protein, Msp1344 of Methanosphaera stadtmanae (Q2NEN2)  
*9.B.97.1.4









Putative fucose 4-O acetylase (346aas; 10 putative TMSs)

Bacteria
Proteobacteria
Fucose 4-O acetylase of Vibrio cholerae (C2ITH3)
*9.B.97.1.5









Acyltransferase 3 of 347 aas and 10 TMSs

Bacteria
Firmicutes
Acyltransferase 3 of Thermoanaerobacterium saccharolyticum
*9.B.97.1.6









Intercellular adhesion protein C of 387 aas and 11 TMSs

Bacteria
Spirochaetes
Adhesion protein C of Leptospira interrogans
*9.B.97.1.7









Polysaccharide adhesin export protein of 350 aas and 10 TMSs, IcaC.  Involved in polysaccharide intercellular adhesin (PIA) export and biofilm formation (Hennig et al. 2007).

Bacteria
Firmicutes
IcaC of Staphylococcus aureus
*9.B.97.1.8









Uncharacterized protein of 358 aas and 11 putative TMSs.

Bacteria
Spirochaetes
UP of Leptospira biflexa
*9.B.97.1.9









Uncharacterized protein of 369 aas and 11 TMSs.

Bacteria
Firmicutes
UP of Clostridium cellulovorans
*9.B.97.1.10









Acyltransferase 3 of 371 aas and 10 TMSs

Bacteria
Proteobacteria
UP of Desulfobulbus propionicus
*9.B.97.1.11









Putative acyltransferase of 363 aas and 10 TMSs.

Bacteria
Actinobacteria
Acyltransferase of Slackia exigua
*9.B.97.1.12









Uncharacterized protein of 369 aas and 10 TMSs.

Bacteria
Firmicutes
UP of Clostridium sp. CAG:167
*9.B.97.2.1









Putative O-acyltransferase homologue (Oac7) (702aas; 14 putative TMSs)

Eukaryota
Metazoa
Oac7 of Caenorhabditis elegans (O45283)
*9.B.97.2.2









Transmembrane acyl transferase of 687 aas and 13 putative TMSs, one at the N-terminus and 12 more together after a hydrophilic domain of about 170 aas, NDG-4.  When the gene is  mutated or deleted, the life span of C. elegans increases up to 5-fold (Brejning et al. 2014).

Eukaryota
Metazoa
NDG-4 of Caenorhabditis elegans
*9.B.97.2.3









Acyl transferase of 822 aas and 14 putative TMSs.  Has an N-terminal TMS followed bya hydrophilic domain of about 270 aas which may include TMSs, followed by about 13 TMSs.  Plays a role in the uptake of a range of molecules including lipids and xenobiotic compounds from the intestine to surrounding tissues. Mediates transport of lipids from the intestine to the reproductive tract. Required for efficient yolk transport into oocytes. Vital for embryonic development (Brejning et al. 2014).  Mutants in the nrf-6 gene have extended lifespans and increased stress resistance (Brejning et al. 2014).

Eukaryota
Metazoa
NRF6 of Caenorhabditis elegans
*9.B.97.3.1









Putative isovaleryltransferase, MppN of 456aas and 10 putative TMSs.

Bacteria
Actinobacteria
MppN of Streptomyces hygroscopicus (Q643C2)
*9.B.97.4.1









Putative O-acetyltransferase, OatA

Bacteria
Proteobacteria
OatA of Erwinia amylovora (YP_003531188)
*9.B.97.4.2









Acyltransferase of 437 aas and 12 TMSs.

Bacteria
Actinobacteria
AT of Nocardia inohanensis
*9.B.97.5.1









Membrane protein with acyltransferase 3 domain

Bacteria
Firmicutes
Acyltransferase of Staphylococcus carnosus
*9.B.97.5.2









Uncharacterized putative acyl transferase of 389 aas and 10 TMSs

Bacteria
Chlamydiae/Verrucomicrobia group
UP of Lentisphaera araneosa
*9.B.97.5.3









Acyltransferase of 329 aas and 10 TMSs.

Bacteria
Proteobacteria
Acyltransferase of Erwinia sp. Ejp617
*9.B.97.6.1









The GumF protein of 364 aas and 10 TMSs (Bianco et al. 2014).

Bacteria
Proteobacteria
GumF of Xanthomonas campestris
*9.B.97.6.2









GumG of 356 aas and 9 or 10 TMSs (Bianco et al. 2014).

Bacteria
Proteobacteria
GumG of Xanthomonas campestris
*9.B.97.6.3









Uncharacterized protein of 333 aas and 9 TMSs.

Bacteria
Firmicutes
UP of Lactobacillus rhamnosus
*9.B.97.7.1









The succinyl transferase, MdoC, OpgC or YmdD (formerly DUF418), is of 385 aas and 10 TMSs. Osmoregulated periplasmic glucans (OPGs) of E. coli are anionic oligosaccharides that accumulate in the periplasmic space in response to low osmolarity of the medium. Their anionic character is provided by the substitution of the glucosidic backbone by phosphoglycerol originating from  membrane phospholipids and by succinyl residues from an unknown origin. The mdoC gene is within the mdoGH operon necessary for the synthesis of the OPG backbone (Lacroix et al. 1999). The same is true for Rhodobacter spheroides in which in correspondng operon is the opgGIHC operon (Cogez et al. 2002).

Bacteria
Proteobacteria
MdoC of E. coli
*9.B.97.7.2









Acyltransferase of 239 aas and 6 TMSs.

Bacteria
Spirochaetes
Acyltransferase of Leptospira interrogans
*9.B.97.7.3









MdoC homologue of 366 aas and 10 TMSs.

Bacteria
Firmicutes
MdoC of Clostridium uliginosum
*9.B.97.7.4









OpgC homologue of 351 aas and 10 TMSs in a 3 + 4 + 3 arrangment.

Bacteria
Proteobacteria
OpgC homolgue of Haemophilus haemolyticus
*9.B.97.7.5









Uncharacterized acyl transferase of 366 aas and 10 TMSs

Bacteria
Bacteroidetes
UP of Zobellia galactanivorans
*9.B.97.7.6









Uncharacterized acyl transferase of 336 aas and 10 TMSs.

Bacteria
Firmicutes
UP of Staphylococcus aureus
*9.B.97.7.7









Uncharacterized acyltransferase of 409 aas ahd 10 TMSs

Bacteria
Actinobacteria
UP of Nocardia flavorosea
*9.B.97.8.1









Succinyl transferase, OpgC or MdoC (formerly DUF418) of 399 aas and 10 TMSs.  It succinylates the osmotically-induced periplasmic oligoglucan (OPG) and is encoded by a gene downstream of the OPG-encoding genes, (opgGIH) (Cogez et al. 2002).

Bacteria
Proteobacteria
ObgC of Rhodobacter sphaeroides
*9.B.97.8.2









OpgC homologue of 397 aas and 10 TMSs in a 3 + 4 + 3 arrangement.

Bacteria
Proteobacteria
OpgC of Aureimonas altamirensis
*9.B.97.8.3









OpgC homologue of 353 aas and 10 TMSs in a 3 + 4 + 3 arrangement.

Bacteria
Candidatus Saccharibacteria
OpgC homolgue of Candidatus Saccharibacteria bacterium
*9.B.97.8.4









OpgC of 397 aas and 10 TMSs in a 3 + 4 + 3 arrangement.

Bacteria
Proteobacteria
OpgC of Klebsiella pneumoniae
*9.B.97.8.5









OpgC homologue of 388 aas and 9 TMSs in a 2 + 4 + 3 arrangement. The N-terminal TMS may be missing because of an incorrect initiation codon assignment.

Bacteria
Actinobacteria
OpgC of Gordonia phthalatica