1.B.37 The Leptospira Porin OmpL1 (LP-OmpL1) Family

Spirochetes of the genus Leptospira possess integral outer membrane β-porins, OmpL1, that can form trimeric structures (Shang et al., 1995). OmpL1 has been reconstituted in planar lipid bilayers where an average single channel conductance of 1.1 nS, similar to the major porin activity of native leptospiral membranes, was demonstrated. Haake and Matsunaga (2010) have reviewed the properties of Leptospiral outer membrane proteins.

The reaction catalyzed by OmpL1 is:

small molecules (periplasm) small molecules (out)

This family belongs to the .



Haake DA. and Matsunaga J. (2010). Leptospira: a spirochaete with a hybrid outer membrane. Mol Microbiol. 77(4):805-14.

Shang, E.S., M.M. Exner, T.A. Summers, C. Martinich, C.I. Champion, R.E. Hancock, and D.A. Haake. (1995). The rare outer membrane protein, OmpL1, of pathogenic Leptospira species is a heat-modifiable porin. Infect. Immun. 63: 3174-3181.


TC#NameOrganismal TypeExample
1.B.37.1.1The OmpL1 porinSpirochetes (Leptospira species)OmpL1 of Leptospira kirschneri



OmopL1 of Leptonema illini


TC#NameOrganismal TypeExample

δ-proteobacterial OmpL1 homologue


Homologue of OmpL1 in Haliangium ochraceum (D0LRV8)