1.B.57 The Legionella Major-Outer Membrane Protein (LM-OMP) Family

The genome of Legionella pneumophila reveals the presence of a large number of genes coding for eukaryotic-like proteins. Khemiri et al. (2008) identified proteins in L. pneumophila whose sequences share similarities with those of eukaryotic polypeptides (lpg0211, lpg1974 and lpg1982). In eukaryotes, the corresponding proteins (PBR, peripheral benzodiazepine receptor; VDAC, voltage-dependant anion channel; and CypD, cyclophilin D) participate in the formation of the mammalian mitochondrial permeability transition pore (MPTP), a complex involved in cell apoptosis. Lpg1974 is a major OMP of Legionella and may be a porin. Multiple paralogues are sometimes formed in a single bacterium.



This family belongs to the Outer Membrane Pore-forming Protein (OMPP) Superfamily I.

 

References:

Khemiri, A., T. Jouenne, and P. Cosette. (2008). Presence in Legionella pneumophila of a mammalian-like mitochondrial permeability transition pore? FEMS Microbiol. Lett. 278: 171-176.

Examples:

TC#NameOrganismal TypeExample
1.B.57.1.1

Legionella Major OMP (LM-OMP) of 297 aas.  It is a voltage-dependent, anion-selective ion permeable porin.

γ-Proteobacteria

LM-OMP of Legionella pneumophila (Q5ZU34)

 
1.B.57.1.2

OMP of 404 aas

α-Proteobacteria

OMP of Rhodopseudomonas palustris (Q21BQ4)

 
1.B.57.1.3

OMP of 392 aas

δ-Proteobacteria

OMP of Pelobacter carbinolicus (Q3A8N9)

 
1.B.57.1.4

Putative porin of 397 aas

Planctomycetes

PP of Pirellula staleyi (Pirella staleyi)

 
1.B.57.1.5

Uncharacterized protein of 557 aas

Cyanobacteria

UP of Oscillatoriales cyanobacterium

 
Examples:

TC#NameOrganismal TypeExample
1.B.57.2.1

OMP of 413 of aas

Planctomyocetes

OMP of Gemmata obscuriglobus (ZP_02735776)

 
1.B.57.2.2

OMP of 403 aas

Planktomyocetes

OMP Blastopirellula marina (A3ZSY5)

 
Examples:

TC#NameOrganismal TypeExample
1.B.57.3.1

OMP of 430 aas

α-Proteobacteria

OMP of Bradyrhizobium sp. BTAi1 (A5EHQ1)

 
1.B.57.3.2

Putative porin of 302 aas

Proteobacteria

Putative porin of Nitrobacter winogradskyi

 
Examples:

TC#NameOrganismal TypeExample
1.B.57.4.1

Uncharacterized protein of 371 aas

Elusimicrobia

UP of Elusimicrobium minutum

 
1.B.57.4.2

Uncharacterized protein of 323 aas

Bacteroidetes

UP of Alistipes putredinis

 
1.B.57.4.3

Uncharacterized protein of 327 aas

Bacteroidetes

UP of Odoribacter splanchnicus

 
1.B.57.4.4

Uncharacterized protein of 326 aas.  This protein is homologous to 8 and 9 repeats in TC protein #s 9.B.133.1.1 and 9.B.133.1.2, respectively in TC Blast searches.

Bacteroidetes

UP of Alistipes shahii

 
1.B.57.4.5

Uncharaterized protein of 382 aas

Bacteroidetes

UP of Pedobacter saltans

 
1.B.57.4.6

Uncharacterized protein of 388 aas

Bacteroidetes

UP of Prevotella melaninogenica