1.B.74 The Outer Membrane Beta Barrel L32 Protein (OmpL32) Family 

Bacterial protein methylation is a widespread post-translational modification that is required for virulence in many pathogenic bacteria. Methylation of outer-membrane proteins modulates the effectiveness of the host immune response. A Leptospira interrogans surface-exposed β-barrel protein undergoes extensive and differential methylation of glutamic acid residues and was designated OmpL32. Expression of OmpL32 occurs during colonization of liver and kidney (Eshghi et al. 2012).  This protein is in the DUF4480 or Peptidase-M14NE family.



This family belongs to the .

 

References:

Eshghi, A., M. Pinne, D.A. Haake, R.L. Zuerner, A. Frank, and C.E. Cameron. (2012). Methylation and in vivo expression of the surface-exposed Leptospira interrogans outer-membrane protein OmpL32. Microbiology 158: 622-635.

Examples:

TC#NameOrganismal TypeExample
1.B.74.1.1

The outer membrane β-barrel protein, OmpL32 (Eshghi et al. 2012).

Spriochaetes

OmpL32 of Leptospira interrogans

 
1.B.74.1.2

Putative porin of 277 aas and 10 - 12 β-strands.

Spirochaetes

Putative porin of Leptospira biflexa

 
1.B.74.1.3

Putative porin of 242 aas

Spirochaetes

Putative porin of Turneriella (Leptospira) parva

 
1.B.74.1.4

Putative porin of 306 aas

Spirochaetes

Putative porin of Leptonema illini