1.B.89.  The Gordonia Outer Membrane Porin (GjpA) Family 

Gordonia jacobaea, belonging to the mycolata group, includes mycolic acids in its cell wall that reduce the permeability of its envelope, requiring the presence of channel-forming proteins to allow the exchange of hydrophilic molecules with the surrounding medium. A cell-wall protein with channel-forming activity, has an average single-channel conductance of 800 pS in 1 M KCl, is moderately anion-selective, and does not show a voltage dependence for voltages between +100 and -100 mV. The channel characteristics suggest that this protein could be of relevance in the import and export of negatively charged molecules across the cell wall (Jiménez-Galisteo et al. 2017).



This family belongs to the .

 

References:

Jiménez-Galisteo, G., E. Fusté, E. Muñoz, T. Vinuesa, T.G. Villa, R. Benz, A. Domínguez, and M. Viñas. (2017). Identification and characterization of a cell wall porin from Gordonia jacobaea. J Gen Appl Microbiol 63: 266-273.

Examples:

TC#NameOrganismal TypeExample
1.B.89.1.1

The pore-forming protein, GjpA of 558 aas and 5 TMSs in a 1 (N-terminal)+ 5 (central) TMS arrangement with a long hydrophilic C-terminal domain.  The channel has an average single-channel conductance of 800 pS in 1 M KCl, is moderately anion-selective, and does not show a voltage dependence for voltages between +100 and -100 mV.GjpA could import and export negatively charged molecules across the cell wall (Jiménez-Galisteo et al. 2017).

GjpA of Gordonia jacobaea

 
1.B.89.1.2

Uncharacterized protein with 476 aas and 4 - 6 predicted TMSs.

UP of Mycolicibacterium smegmatis

 
1.B.89.1.3

PE family protein of 503 aas and an uncertain number of TMSs. The PE family is described under TC# 9.B.96 and is also called the PE-PGRS Family.

PE family protein of Mycobacterium gordonae

 
1.B.89.1.4

Uncharacterized protein of 482 aas and 5 putative TMSs.

UP of Gordonia polyisoprenivorans