8.A.15 The K+ Channel Accessory Protein (KChAP) Family

The KChAP family consists of proteins from yeast, plants and animals. The best characterized homologues are from mammals. KChAP interacts with the Kv2 principal subunits of the VIC superfamily, enhancing current levels and surface expression of Kv2 without affecting gating or kinetics. It may function as a chaperone subunit.

This family belongs to the .



Coetzee, W.A., Y. Amalillo, J. Chiu, A. Chow, D. Lau, T. McCormack, H. Moreno, M.S. Nadal, A. Ozaita, D. Pountney, M. Saganich, E. Vega-Saenz de Miera, and B. Rudy (1999). Molecular diversity of K+ channels. Ann. N.Y. Acad. Sci USA 868: 233-285.

Mangubat, E.Z., T.-T. Tseng, and E. Jakobsson. (2003). Phylogenetic analyses of potassium channel auxiliary subunits. J. Mol. Microbiol. Biotechnol. (in press).


TC#NameOrganismal TypeExample
8.A.15.1.1K+ channel auxiliary subunit (KChAP)AnimalsKChAP of Mus musculus

Zinc finger MIZ domain-containing protein 2, isoform X4 of 897 aas, zf-MIZ or ZMIZ2. Shows extensive sequence similarity with 8.A.15.1.1 with residues 517 - 677 in the former protein aligning with residues 276 - 425 of the latter with a score of e-18 in TC BLAST.  No function related to a transporter has been identified.

zf-MIZ2 of Homo sapiens